@article{a8a033d00f774b3f817aa13d4f8594a3,
title = "Post-error recruitment of frontal sensory cortical projections promotes attention in mice",
abstract = "The frontal cortex, especially the anterior cingulate cortex area (ACA), is essential for exerting cognitive control after errors, but the mechanisms that enable modulation of attention to improve performance after errors are poorly understood. Here we demonstrate that during a mouse visual attention task, ACA neurons projecting to the visual cortex (VIS; ACAVIS neurons) are recruited selectively by recent errors. Optogenetic manipulations of this pathway collectively support the model that rhythmic modulation of ACAVIS neurons in anticipation of visual stimuli is crucial for adjusting performance following errors. 30-Hz optogenetic stimulation of ACAVIS neurons in anesthetized mice recapitulates the increased gamma and reduced theta VIS oscillatory changes that are associated with endogenous post-error performance during behavior and subsequently increased visually evoked spiking, a hallmark feature of visual attention. This frontal sensory neural circuit links error monitoring with implementing adjustments of attention to guide behavioral adaptation, pointing to a circuit-based mechanism for promoting cognitive control.",
keywords = "attention, cognitive control, error monitoring, frontal cortex, frontal sensory cortical projection, top-down, visual cortex",
author = "Norman, {Kevin J.} and Riceberg, {Justin S.} and Hiroyuki Koike and Julia Bateh and McCraney, {Sarah E.} and Keaven Caro and Daisuke Kato and Ana Liang and Kazuhiko Yamamuro and Flanigan, {Meghan E.} and Korey Kam and Falk, {Elisa N.} and Brady, {Daniel M.} and Christina Cho and Masato Sadahiro and Kohei Yoshitake and Priscilla Maccario and Demars, {Michael P.} and Leah Waltrip and Varga, {Andrew W.} and Russo, {Scott J.} and Baxter, {Mark G.} and Shapiro, {Matthew L.} and Rudebeck, {Peter H.} and Hirofumi Morishita",
note = "Funding Information: This work was funded by NIH F31MH121010 (to K.J.N.); NIH F30MH111143 ; the Beatrice and Samuel A. Seaver Foundation (to E.N.F.); R01MH073689 (to M.L.S.); and NIH R21NS105119 , R21MH106919 , R01EY024918 , and R01MH119523 (to H.M.). We thank Dr. Erin Rich, Nick Upright, and members of the Morishita lab for helpful feedback and the NVIDIA Corporation. Funding Information: This work was funded by NIH F31MH121010 (to K.J.N.); NIH F30MH111143; the Beatrice and Samuel A. Seaver Foundation (to E.N.F.); R01MH073689 (to M.L.S.); and NIH R21NS105119, R21MH106919, R01EY024918, and R01MH119523 (to H.M.). We thank Dr. Erin Rich, Nick Upright, and members of the Morishita lab for helpful feedback and the NVIDIA Corporation. K.J.N. H.K. and H.M. designed the experiments. K.J.N. and H.M. performed analyses and wrote the manuscript with contributions from all co-authors. K.J.N. performed fiber photometry and optogenetics experiments with assistance from H.K. J.B. S.E.M. K.C. C.C. E.N.F. M.P.D. P.M. and L.W. K. Yamamuro performed slice electrophysiology. A.L. D.K. M.S. and K. Yoshitake performed in vivo electrophysiology experiments. J.S.R. and M.L.S. analyzed spike/LFP/EEG data, and J.B. and P.H.R. assisted with analysis. M.E.F. and S.J.R. provided expertise regarding photometry methodology. K.K. and A.W.V. provided expertise regarding EEG recording methodology. D.M.B. wrote the Python script for fiber photometry analysis. M.G.B. provided guidance regarding behavioral experiments and statistical analysis. H.M. supervised the research. The authors declare no competing interests. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in science. One or more of the authors of this paper self-identifies as a member of the LGBTQ+ community. One or more of the authors of this paper self-identifies as living with a disability. While citing references scientifically relevant for this work, we also actively worked to promote gender balance in our reference list. The author list of this paper includes contributors from the location where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = apr,
day = "7",
doi = "10.1016/j.neuron.2021.02.001",
language = "English",
volume = "109",
pages = "1202--1213.e5",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "7",
}