Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease

Masaki Miyazawa; Masahiro Yanagi; Tomoyoshi Chiba; Hidenori Kido; Toshiki Matsuo; Masaki Nishitani; Noriaki Orita; Noboru Takata; Tomoyuki Hayashi; Akihiro Seki; Hidetoshi Nakagawa; Kouki Nio; Takeshi Terashima; Noriho Iida; Shinya Yamada; Hajime Takatori; Tetsuro Shimakami; Kuniaki Arai; Tatsuya Yamashita; Eishiro Mizukoshi; Masao Honda; Taro Yamashita

doi:10.2169/internalmedicine.2489-23

Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease

Masaki Miyazawa
, Masahiro Yanagi
, Tomoyoshi Chiba
, Hidenori Kido
, Toshiki Matsuo
, Masaki Nishitani
, Noriaki Orita
, Noboru Takata
, Tomoyuki Hayashi
, Akihiro Seki
, Hidetoshi Nakagawa
, Kouki Nio
, Takeshi Terashima
, Noriho Iida
, Shinya Yamada
, Hajime Takatori
, Tetsuro Shimakami
, Kuniaki Arai
, Tatsuya Yamashita
, Eishiro Mizukoshi

Masao Honda, Taro Yamashita

Research output: Contribution to journal › Article › peer-review

Abstract

We herein report a rare case of idiopathic portal hypertension (IPH)-like disease that developed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A 53-year-old woman who underwent allo-HSCT for acute myeloid leukemia showed portal hypertension with radiological and histopathological findings consistent with IPH, distinct from veno-occlusive disease (VOD) and graft-versus-host disease (GVHD) of the liver. This case highlights the importance of considering IPH-like disease as a potential cause of portal hypertension after allo-HSCT. Awareness of this complication can aid in the early diagnosis and appropriate management of patients post allo-HSCT.

Original language	English
Pages (from-to)	1563-1568
Number of pages	6
Journal	Internal Medicine
Volume	63
Issue number	11
DOIs	https://doi.org/10.2169/internalmedicine.2489-23
State	Published - 2024
Externally published	Yes

Keywords

allogeneic hematopoietic stem cell transplantation
esophageal varices
graft-versus-host disease
idiopathic portal hypertension
veno-occlusive disease

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10.2169/internalmedicine.2489-23

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Miyazawa, M., Yanagi, M., Chiba, T., Kido, H., Matsuo, T., Nishitani, M., Orita, N., Takata, N., Hayashi, T., Seki, A., Nakagawa, H., Nio, K., Terashima, T., Iida, N., Yamada, S., Takatori, H., Shimakami, T., Arai, K., Yamashita, T., ... Yamashita, T. (2024). Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease. Internal Medicine, 63(11), 1563-1568. https://doi.org/10.2169/internalmedicine.2489-23

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title = "Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease",

abstract = "We herein report a rare case of idiopathic portal hypertension (IPH)-like disease that developed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A 53-year-old woman who underwent allo-HSCT for acute myeloid leukemia showed portal hypertension with radiological and histopathological findings consistent with IPH, distinct from veno-occlusive disease (VOD) and graft-versus-host disease (GVHD) of the liver. This case highlights the importance of considering IPH-like disease as a potential cause of portal hypertension after allo-HSCT. Awareness of this complication can aid in the early diagnosis and appropriate management of patients post allo-HSCT.",

keywords = "allogeneic hematopoietic stem cell transplantation, esophageal varices, graft-versus-host disease, idiopathic portal hypertension, veno-occlusive disease",

author = "Masaki Miyazawa and Masahiro Yanagi and Tomoyoshi Chiba and Hidenori Kido and Toshiki Matsuo and Masaki Nishitani and Noriaki Orita and Noboru Takata and Tomoyuki Hayashi and Akihiro Seki and Hidetoshi Nakagawa and Kouki Nio and Takeshi Terashima and Noriho Iida and Shinya Yamada and Hajime Takatori and Tetsuro Shimakami and Kuniaki Arai and Tatsuya Yamashita and Eishiro Mizukoshi and Masao Honda and Taro Yamashita",

note = "Publisher Copyright: {\textcopyright} 2024 The Japanese Society of Internal Medicine.",

year = "2024",

doi = "10.2169/internalmedicine.2489-23",

language = "English",

volume = "63",

pages = "1563--1568",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

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Miyazawa, M, Yanagi, M, Chiba, T, Kido, H, Matsuo, T, Nishitani, M, Orita, N, Takata, N, Hayashi, T, Seki, A, Nakagawa, H, Nio, K, Terashima, T, Iida, N, Yamada, S, Takatori, H, Shimakami, T, Arai, K, Yamashita, T, Mizukoshi, E, Honda, M & Yamashita, T 2024, 'Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease', Internal Medicine, vol. 63, no. 11, pp. 1563-1568. https://doi.org/10.2169/internalmedicine.2489-23

TY - JOUR

T1 - Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease

AU - Miyazawa, Masaki

AU - Yanagi, Masahiro

AU - Chiba, Tomoyoshi

AU - Kido, Hidenori

AU - Matsuo, Toshiki

AU - Nishitani, Masaki

AU - Orita, Noriaki

AU - Takata, Noboru

AU - Hayashi, Tomoyuki

AU - Seki, Akihiro

AU - Nakagawa, Hidetoshi

AU - Nio, Kouki

AU - Terashima, Takeshi

AU - Iida, Noriho

AU - Yamada, Shinya

AU - Takatori, Hajime

AU - Shimakami, Tetsuro

AU - Arai, Kuniaki

AU - Yamashita, Tatsuya

AU - Mizukoshi, Eishiro

AU - Honda, Masao

AU - Yamashita, Taro

PY - 2024

Y1 - 2024

N2 - We herein report a rare case of idiopathic portal hypertension (IPH)-like disease that developed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A 53-year-old woman who underwent allo-HSCT for acute myeloid leukemia showed portal hypertension with radiological and histopathological findings consistent with IPH, distinct from veno-occlusive disease (VOD) and graft-versus-host disease (GVHD) of the liver. This case highlights the importance of considering IPH-like disease as a potential cause of portal hypertension after allo-HSCT. Awareness of this complication can aid in the early diagnosis and appropriate management of patients post allo-HSCT.

AB - We herein report a rare case of idiopathic portal hypertension (IPH)-like disease that developed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). A 53-year-old woman who underwent allo-HSCT for acute myeloid leukemia showed portal hypertension with radiological and histopathological findings consistent with IPH, distinct from veno-occlusive disease (VOD) and graft-versus-host disease (GVHD) of the liver. This case highlights the importance of considering IPH-like disease as a potential cause of portal hypertension after allo-HSCT. Awareness of this complication can aid in the early diagnosis and appropriate management of patients post allo-HSCT.

KW - allogeneic hematopoietic stem cell transplantation

KW - esophageal varices

KW - graft-versus-host disease

KW - idiopathic portal hypertension

KW - veno-occlusive disease

UR - https://www.scopus.com/pages/publications/85194726404

U2 - 10.2169/internalmedicine.2489-23

DO - 10.2169/internalmedicine.2489-23

M3 - Article

C2 - 37839881

AN - SCOPUS:85194726404

SN - 0918-2918

VL - 63

SP - 1563

EP - 1568

JO - Internal Medicine

JF - Internal Medicine

IS - 11

ER -

Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease

Abstract

Keywords

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