Possible involvement of protein kinase C in interleukin-1 production by mouse peritoneal macrophages

Yuko Katakami, Yoshinobu Nakao, Toshimitsu Matsui, Tamio Koizumi, Kozo Kaibuchi, Yoshimi Takai, Takuo Fujita

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Both lipopolysaccharide (LPS) and phorbol-12,13-dibutyrate (PDBu), a protein kinase C-activating phorbol ester, induced interleukin-1 (IL-1) production in mouse peritoneal macrophages. Prolonged treatment of the cells with PDBu led to the down-regulation and complete disappearance of protein kinase C. In these cells, PDBu did not increase IL-1 production, but LPS still stimulated IL-1 production although the maximum level was slightly reduced. These results suggest that protein kinase C and another unknown signal pathway are involved in LPS-induced IL-1 production.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume135
Issue number2
DOIs
StatePublished - 13 Mar 1986
Externally publishedYes

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