Positron emission tomography (PET) used to image subclinical inflammation associated with ulcerative colitis (UC) in remission

David T. Rubin, Bonnie L. Surma, Samuel J. Gavzy, Kerry M. Schnell, Alana P. Bunnag, Dezheng Huo, Daniel E. Appelbaum

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background: Positron emission tomography (PET) using 18-fluorodeoxyglucose (18-FDG) is a noninvasive, functional imaging modality most often used to assess cancer. The aim of this study was to perform PET/computed tomography (CT) on patients with quiescent ulcerative colitis (UC) to understand the limits of this technology for assessing inflammatory activity. Methods: We identified patients diagnosed with UC in a strictly defined remission state. PET/CT was performed in standard fashion, using approximately 10 mCi of 18-FDG with a 60-minute uptake delay. Uptake in each of 4 colonic segments (recto-sigmoid [r-s], descending, transverse, and ascending), and distal small bowel were scored on a 3-point scale (0 = no uptake or uptake ≤liver; 1 = uptake somewhat >liver; 2 = uptake much greater than liver). Results: Ten patients participated in this study, 6 male. Eight had pancolitis, 1 had extensive colitis, and 1 had procto-sigmoiditis, with a median disease duration was 32 years. A PET scan was performed mean 37 days after endoscopy. Six patients had no increased 18-FDG uptake, 3 had increased uptake in the r-s region, 1 patient with r-s uptake also had ascending colon uptake, and 1 had ileal uptake with no colonic signal. Conclusions: In this study, PET demonstrated inflammatory activity in the colon despite negative endoscopic, histologic, and symptom assessment. This has important implications in the understanding of UC disease quiescence. Further exploration of this highly sensitive modality should be performed.

Original languageEnglish
Pages (from-to)750-755
Number of pages6
JournalInflammatory Bowel Diseases
Volume15
Issue number5
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Positron emission tomography
  • Quiescent inflammatory bowel disease
  • Ulcerative colitis

Fingerprint

Dive into the research topics of 'Positron emission tomography (PET) used to image subclinical inflammation associated with ulcerative colitis (UC) in remission'. Together they form a unique fingerprint.

Cite this