Positron emission tomography assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder

Monte S. Buchsbaum; Joseph Wu; Richard Haier; Erin Hazlett; Ron Ball; Mark Katz; Ken Sokolski; Manuel Lagunas-Solar; Dennis Langer

doi:10.1016/0024-3205(87)90753-3

Positron emission tomography assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder

Monte S. Buchsbaum, Joseph Wu, Richard Haier, Erin Hazlett, Ron Ball, Mark Katz, Ken Sokolski, Manuel Lagunas-Solar, Dennis Langer

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Patients with generalized anxiety disorder (n = 18) entered a 21-day, double-blind, placebo-controlled random assignment trial of clorazepate. Positron emission tomography with ¹⁸F-deoxyglucose was carried out before and after treatment. Decreases in glucose metabolic rate in visual cortex and relative increases in the basal ganglia and thalamus were found. A correlation between regional changes in metabolic rate and regional benzodiazepine receptor binding density from other human autopsy studies was observed; brain regions highest in receptor density showed the greatest decrease in rate.

Original language	English
Pages (from-to)	2393-2400
Number of pages	8
Journal	Life Sciences
Volume	40
Issue number	25
DOIs	https://doi.org/10.1016/0024-3205(87)90753-3
State	Published - 22 Jun 1987
Externally published	Yes

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title = "Positron emission tomography assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder",

abstract = "Patients with generalized anxiety disorder (n = 18) entered a 21-day, double-blind, placebo-controlled random assignment trial of clorazepate. Positron emission tomography with 18F-deoxyglucose was carried out before and after treatment. Decreases in glucose metabolic rate in visual cortex and relative increases in the basal ganglia and thalamus were found. A correlation between regional changes in metabolic rate and regional benzodiazepine receptor binding density from other human autopsy studies was observed; brain regions highest in receptor density showed the greatest decrease in rate.",

author = "Buchsbaum, {Monte S.} and Joseph Wu and Richard Haier and Erin Hazlett and Ron Ball and Mark Katz and Ken Sokolski and Manuel Lagunas-Solar and Dennis Langer",

note = "Funding Information: This work was supported by a grant from Abbott Laboratories. We also appreciate the discussions of Charles Ribak, Ph.D., in the Department of Neuroanatomy at the University of California, Irvine.",

year = "1987",

month = jun,

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doi = "10.1016/0024-3205(87)90753-3",

language = "English",

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T1 - Positron emission tomography assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder

AU - Buchsbaum, Monte S.

AU - Wu, Joseph

AU - Haier, Richard

AU - Hazlett, Erin

AU - Ball, Ron

AU - Katz, Mark

AU - Sokolski, Ken

AU - Lagunas-Solar, Manuel

AU - Langer, Dennis

N1 - Funding Information: This work was supported by a grant from Abbott Laboratories. We also appreciate the discussions of Charles Ribak, Ph.D., in the Department of Neuroanatomy at the University of California, Irvine.

PY - 1987/6/22

Y1 - 1987/6/22

N2 - Patients with generalized anxiety disorder (n = 18) entered a 21-day, double-blind, placebo-controlled random assignment trial of clorazepate. Positron emission tomography with 18F-deoxyglucose was carried out before and after treatment. Decreases in glucose metabolic rate in visual cortex and relative increases in the basal ganglia and thalamus were found. A correlation between regional changes in metabolic rate and regional benzodiazepine receptor binding density from other human autopsy studies was observed; brain regions highest in receptor density showed the greatest decrease in rate.

AB - Patients with generalized anxiety disorder (n = 18) entered a 21-day, double-blind, placebo-controlled random assignment trial of clorazepate. Positron emission tomography with 18F-deoxyglucose was carried out before and after treatment. Decreases in glucose metabolic rate in visual cortex and relative increases in the basal ganglia and thalamus were found. A correlation between regional changes in metabolic rate and regional benzodiazepine receptor binding density from other human autopsy studies was observed; brain regions highest in receptor density showed the greatest decrease in rate.

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DO - 10.1016/0024-3205(87)90753-3

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AN - SCOPUS:0023224965

SN - 0024-3205

VL - 40

SP - 2393

EP - 2400

JO - Life Sciences

JF - Life Sciences

IS - 25

ER -

Positron emission tomography assessment of effects of benzodiazepines on regional glucose metabolic rate in patients with anxiety disorder

Abstract

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