TY - JOUR
T1 - Positron emission tomography and single-photon emission computed tomography in substance abuse research
AU - Volkow, Nora D.
AU - Fowler, Joanna S.
AU - Wang, Gene Jack
N1 - Funding Information:
This work was carried out at Brookhaven National Laboratory under contract DE-AC02-98CH10886 and with the U. S. Department of Energy and supported by its Office of Biological and Environmental Research and also by the National Institutes of Health (National Institute on Drug Abuse and National Institutes of Neurological Diseases and Stroke).
PY - 2003/4
Y1 - 2003/4
N2 - Many advances in the conceptualization of addiction as a disease of the brain have come from the application of imaging technologies directly in the human drug abuser. New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) and single-photon emission computed tomography (SPECT) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology, and medicine. This topic cuts across the medical specialties of neurology, psychiatry, oncology, and cardiology because of the high medical, social, and economic toll that drugs of abuse, including the legal drugs, cigarettes and alcohol, take on society. This article highlights recent advances in the use of PET and SPECT imaging to measure the pharmacokinetic and pharmacodynamic effects of drugs of abuse on the human brain.
AB - Many advances in the conceptualization of addiction as a disease of the brain have come from the application of imaging technologies directly in the human drug abuser. New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) and single-photon emission computed tomography (SPECT) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology, and medicine. This topic cuts across the medical specialties of neurology, psychiatry, oncology, and cardiology because of the high medical, social, and economic toll that drugs of abuse, including the legal drugs, cigarettes and alcohol, take on society. This article highlights recent advances in the use of PET and SPECT imaging to measure the pharmacokinetic and pharmacodynamic effects of drugs of abuse on the human brain.
UR - http://www.scopus.com/inward/record.url?scp=0038273909&partnerID=8YFLogxK
U2 - 10.1053/snuc.2003.127300
DO - 10.1053/snuc.2003.127300
M3 - Article
C2 - 12756644
AN - SCOPUS:0038273909
SN - 0001-2998
VL - 33
SP - 114
EP - 128
JO - Seminars in Nuclear Medicine
JF - Seminars in Nuclear Medicine
IS - 2
ER -