Positron emission tomography and computed tomography assessments of the aging human brain

Mony J. De Leon; Ajax E. George; Steven H. Ferris; David R. Christman; Joanna S. Fowler; Cynthia I. Gentes; Jonathan Brodie; Barry Reisberg; Alfred P. Wolf

doi:10.1097/00004728-198402000-00017

Positron emission tomography and computed tomography assessments of the aging human brain

Mony J. De Leon, Ajax E. George, Steven H. Ferris, David R. Christman, Joanna S. Fowler, Cynthia I. Gentes, Jonathan Brodie, Barry Reisberg, Alfred P. Wolf

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

The relationship between alterations in brain structure and brain function was studied in vivo in both young and elderly human subjects. Computed tomography revealed significant age-related ventricular and cortical sulcal dilatation. The cortical changes were most closely related to age. Positron emission tomography failed to show regional changes in brain glucose metabolic rate. The results suggest that the normal aging brain undergoes structural atrophic changes without incurring regional metabolic changes. Examination of the correlations between the structural and the metabolic measures revealed no significant relationships. These data are discussed with respect to the significant structure-function relationships that have been reported in Alzheimer disease.

Original language	English
Pages (from-to)	88-94
Number of pages	7
Journal	Journal of Computer Assisted Tomography
Volume	8
Issue number	1
DOIs	https://doi.org/10.1097/00004728-198402000-00017
State	Published - Feb 1984
Externally published	Yes

Keywords

Age and aging
Atrophy
Brain
Computed tomography
Emission computed tomography
F-2- Deoxyglucose

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10.1097/00004728-198402000-00017

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title = "Positron emission tomography and computed tomography assessments of the aging human brain",

abstract = "The relationship between alterations in brain structure and brain function was studied in vivo in both young and elderly human subjects. Computed tomography revealed significant age-related ventricular and cortical sulcal dilatation. The cortical changes were most closely related to age. Positron emission tomography failed to show regional changes in brain glucose metabolic rate. The results suggest that the normal aging brain undergoes structural atrophic changes without incurring regional metabolic changes. Examination of the correlations between the structural and the metabolic measures revealed no significant relationships. These data are discussed with respect to the significant structure-function relationships that have been reported in Alzheimer disease.",

keywords = "Age and aging, Atrophy, Brain, Computed tomography, Emission computed tomography, F-2- Deoxyglucose",

author = "{De Leon}, {Mony J.} and George, {Ajax E.} and Ferris, {Steven H.} and Christman, {David R.} and Fowler, {Joanna S.} and Gentes, {Cynthia I.} and Jonathan Brodie and Barry Reisberg and Wolf, {Alfred P.}",

year = "1984",

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T1 - Positron emission tomography and computed tomography assessments of the aging human brain

AU - De Leon, Mony J.

AU - George, Ajax E.

AU - Ferris, Steven H.

AU - Christman, David R.

AU - Fowler, Joanna S.

AU - Gentes, Cynthia I.

AU - Brodie, Jonathan

AU - Reisberg, Barry

AU - Wolf, Alfred P.

PY - 1984/2

Y1 - 1984/2

N2 - The relationship between alterations in brain structure and brain function was studied in vivo in both young and elderly human subjects. Computed tomography revealed significant age-related ventricular and cortical sulcal dilatation. The cortical changes were most closely related to age. Positron emission tomography failed to show regional changes in brain glucose metabolic rate. The results suggest that the normal aging brain undergoes structural atrophic changes without incurring regional metabolic changes. Examination of the correlations between the structural and the metabolic measures revealed no significant relationships. These data are discussed with respect to the significant structure-function relationships that have been reported in Alzheimer disease.

AB - The relationship between alterations in brain structure and brain function was studied in vivo in both young and elderly human subjects. Computed tomography revealed significant age-related ventricular and cortical sulcal dilatation. The cortical changes were most closely related to age. Positron emission tomography failed to show regional changes in brain glucose metabolic rate. The results suggest that the normal aging brain undergoes structural atrophic changes without incurring regional metabolic changes. Examination of the correlations between the structural and the metabolic measures revealed no significant relationships. These data are discussed with respect to the significant structure-function relationships that have been reported in Alzheimer disease.

KW - Age and aging

KW - Atrophy

KW - Brain

KW - Computed tomography

KW - Emission computed tomography

KW - F-2- Deoxyglucose

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Positron emission tomography and computed tomography assessments of the aging human brain

Abstract

Keywords

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