Positron emission tomographic studies of aging and Alzheimer disease.

M. J. de Leon; S. H. Ferris; A. E. George; D. R. Christman; J. S. Fowler; C. Gentes; B. Reisberg; B. Gee; M. Emmerich; Y. Yonekura; J. Brodie; I. I. Kricheff; A. P. Wolf

Positron emission tomographic studies of aging and Alzheimer disease.

M. J. de Leon, S. H. Ferris, A. E. George, D. R. Christman, J. S. Fowler, C. Gentes, B. Reisberg, B. Gee, M. Emmerich, Y. Yonekura, J. Brodie, I. I. Kricheff, A. P. Wolf

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187 Scopus citations

Abstract

In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.

Original language	English
Pages (from-to)	568-571
Number of pages	4
Journal	American Journal of Neuroradiology
Volume	4
Issue number	3
State	Published - May 1983

Cite this

@article{eb50f48f8b4b4371823ea41885ac6451,

title = "Positron emission tomographic studies of aging and Alzheimer disease.",

abstract = "In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17\%-24\%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80\% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.",

author = "\{de Leon\}, \{M. J.\} and Ferris, \{S. H.\} and George, \{A. E.\} and Christman, \{D. R.\} and Fowler, \{J. S.\} and C. Gentes and B. Reisberg and B. Gee and M. Emmerich and Y. Yonekura and J. Brodie and Kricheff, \{I. I.\} and Wolf, \{A. P.\}",

year = "1983",

month = may,

language = "English",

volume = "4",

pages = "568--571",

journal = "American Journal of Neuroradiology",

issn = "0195-6108",

publisher = "American Society of Neuroradiology",

number = "3",

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TY - JOUR

T1 - Positron emission tomographic studies of aging and Alzheimer disease.

AU - de Leon, M. J.

AU - Ferris, S. H.

AU - George, A. E.

AU - Christman, D. R.

AU - Fowler, J. S.

AU - Gentes, C.

AU - Reisberg, B.

AU - Gee, B.

AU - Emmerich, M.

AU - Yonekura, Y.

AU - Brodie, J.

AU - Kricheff, I. I.

AU - Wolf, A. P.

PY - 1983/5

Y1 - 1983/5

N2 - In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.

AB - In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.

UR - https://www.scopus.com/pages/publications/0020758778

M3 - Article

C2 - 6410799

AN - SCOPUS:0020758778

SN - 0195-6108

VL - 4

SP - 568

EP - 571

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

IS - 3

ER -

Positron emission tomographic studies of aging and Alzheimer disease.

Abstract

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