Positive regulation of human thyrotropin receptor mrna by thyrotropin

Gerold K. Huber, Erlinda S. Concepcion, Peter N. Graves, Terry F. Davies

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

We have assessed the influence of natural and recombinant thyrotropin (TSH) on mRNA specific for the human TSH receptor (TSHR) in normal and abnormal adult human thyroid monolayer cells. Using physiological concentrations of TSH (<100 mU/L), a marked increase in the level of TSHR mRNA was observed within 12 hours and reached a >1000% increase after 24 hours exposure. At high TSH concentrations (>1000 mU/L), this increase in TSHR-specific mRNA was markedly reduced. However, at no time were basal TSHR mRNA levels suppressed even with 100 U/L of TSH for 48 hours. These observations demonstrate ligand-induced up-regulation of the human TSHR mRNA by physiologically relevant concentrations of TSH.

Original languageEnglish
Pages (from-to)1394-1396
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume72
Issue number6
DOIs
StatePublished - Jun 1991

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