TY - JOUR
T1 - Positive psychological well-being and clinical characteristics in IBS
T2 - A systematic review
AU - Madva, Elizabeth N.
AU - Sadlonova, Monika
AU - Harnedy, Lauren E.
AU - Longley, Regina M.
AU - Amonoo, Hermioni L.
AU - Feig, Emily H.
AU - Millstein, Rachel A.
AU - Zambrano, Juliana
AU - Rojas Amaris, Alexandra
AU - Jurayj, Jane
AU - Burton Murray, Helen
AU - Staller, Kyle
AU - Kuo, Braden
AU - Keefer, Laurie
AU - Huffman, Jeff C.
AU - Celano, Christopher M.
N1 - Funding Information:
Time for analysis and article preparation was funded by the National Institute of Diabetes and Digestive and Kidney Diseases , K23DK120945 (KS), K23DK131334 (HBM), R01DK121003 (BK), and U01DK112193 (BK), and the National Heart, Lung, and Blood Institute , R01HL155301 (CMC), R01HL133149 (JCH), K23HL135277 (RAM), and K23HL148017 (EHF), National Cancer Institute , K08CA251654 (HLA), the Harvard Medical School Dupont Warren Research Fellowship (ENM), and the German Heart Foundation (MS). The study sponsors had no role in the study design, collection, analysis, or interpretation of the data or writing of the report.
Funding Information:
Time for analysis and article preparation was funded by the National Institute of Diabetes and Digestive and Kidney Diseases, K23DK120945 (KS), K23DK131334 (HBM), R01DK121003 (BK), and U01DK112193 (BK), and the National Heart, Lung, and Blood Institute, R01HL155301 (CMC), R01HL133149 (JCH), K23HL135277 (RAM), and K23HL148017 (EHF), National Cancer Institute, K08CA251654 (HLA), the Harvard Medical School Dupont Warren Research Fellowship (ENM), and the German Heart Foundation (MS). The study sponsors had no role in the study design, collection, analysis, or interpretation of the data or writing of the report.There are no conflicts of interest to declare related to this research. KS has received support from Ironwood and Urovant and has served as a consultant to Anji, Arena, Gelesis, GI Supply, Sanofi, and Shire/Takeda. HBM receives royalties from Oxford University Press for her forthcoming book on rumination syndrome. CMC has received salary support for research from BioXcel Pharmaceuticals and honoraria for talks to Sunovion Pharmaceuticals on topics unrelated to this research. BK has received research support from Medtronic, Gelesis, Takeda, Vanda, and consulting/speaking arrangements with Arena, CinDom, Cin Rx, Medtronic, Entrega, Ironwood, Neurogastrix, Phathom, Serepta, Sigma Wasserman, and Takeda. LK receives consulting fees from Lilly, Takeda, Pfizer, Abbvie, Reckitt Health and Trellus Health, and is a co-founder/equity owner for Trellus Health. There are no other funding sources to declare.
Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Objective: Psychological factors (e.g., depression, anxiety) are known to contribute to the development and maintenance of irritable bowel syndrome (IBS). Less is known, however, about the role of positive psychological well-being (PPWB) in IBS. Accordingly, we completed a systematic review of the literature examining relationships between PPWB and clinical characteristics in IBS. Method: A systematic review using search terms related to PPWB and IBS from inception through July 28, 2022, was completed. Quality was assessed with the NIH Quality Assessment Tool. A narrative synthesis of findings, rather than meta-analysis, was completed due to study heterogeneity. Results: 22 articles with a total of 4285 participants with IBS met inclusion criteria. Individuals with IBS had lower levels of PPWB (e.g., resilience, positive affect, self-efficacy, emotion regulation) compared to healthy populations, which in turn was associated with reduced physical and mental health and health-related quality of life (HRQoL). Limited exploration of potential biological mechanisms underlying these relationships has been described. Conclusions: PPWB is diminished in individuals with IBS compared to other populations, and greater PPWB is linked to superior physical, psychological, and HRQoL outcomes. Interventions to increase PPWB may have the potential to improve IBS-related outcomes. Registration: Prospective Register of Systematic Reviews CRD42022304767.
AB - Objective: Psychological factors (e.g., depression, anxiety) are known to contribute to the development and maintenance of irritable bowel syndrome (IBS). Less is known, however, about the role of positive psychological well-being (PPWB) in IBS. Accordingly, we completed a systematic review of the literature examining relationships between PPWB and clinical characteristics in IBS. Method: A systematic review using search terms related to PPWB and IBS from inception through July 28, 2022, was completed. Quality was assessed with the NIH Quality Assessment Tool. A narrative synthesis of findings, rather than meta-analysis, was completed due to study heterogeneity. Results: 22 articles with a total of 4285 participants with IBS met inclusion criteria. Individuals with IBS had lower levels of PPWB (e.g., resilience, positive affect, self-efficacy, emotion regulation) compared to healthy populations, which in turn was associated with reduced physical and mental health and health-related quality of life (HRQoL). Limited exploration of potential biological mechanisms underlying these relationships has been described. Conclusions: PPWB is diminished in individuals with IBS compared to other populations, and greater PPWB is linked to superior physical, psychological, and HRQoL outcomes. Interventions to increase PPWB may have the potential to improve IBS-related outcomes. Registration: Prospective Register of Systematic Reviews CRD42022304767.
KW - Functional gastrointestinal disorders
KW - Irritable bowel syndrome
KW - Psychology, positive
KW - Psychosomatic medicine
UR - http://www.scopus.com/inward/record.url?scp=85146666866&partnerID=8YFLogxK
U2 - 10.1016/j.genhosppsych.2023.01.004
DO - 10.1016/j.genhosppsych.2023.01.004
M3 - Review article
C2 - 36681019
AN - SCOPUS:85146666866
SN - 0163-8343
VL - 81
SP - 1
EP - 14
JO - General Hospital Psychiatry
JF - General Hospital Psychiatry
ER -