Portal hypertension associated with systemic mastocytosis and splenomegaly

Sharon Grundfest; Avram M. Cooperman; Roy Ferguson; Sanford Benjamin

doi:10.1016/0016-5085(80)90591-0

Portal hypertension associated with systemic mastocytosis and splenomegaly

Sharon Grundfest, Avram M. Cooperman, Roy Ferguson, Sanford Benjamin

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38 Scopus citations

Abstract

An unusual case of systemic mastocytosis with splenomegaly, portal hypertension, and bleeding esophageal varices is presented. Arteriograms and liver biopsy suggested the mechanism of the portal hypertension was due to increased blood flow in the splenic vein, although splenic arteriovenous shunting secondary to histamine release and increased intrahepatic resistance secondary to mast cell infiltration might have played a role. The portal hypertension was relieved by splenectomy.

Original language	English
Pages (from-to)	370-373
Number of pages	4
Journal	Gastroenterology
Volume	78
Issue number	2
DOIs	https://doi.org/10.1016/0016-5085(80)90591-0
State	Published - Feb 1980
Externally published	Yes

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title = "Portal hypertension associated with systemic mastocytosis and splenomegaly",

abstract = "An unusual case of systemic mastocytosis with splenomegaly, portal hypertension, and bleeding esophageal varices is presented. Arteriograms and liver biopsy suggested the mechanism of the portal hypertension was due to increased blood flow in the splenic vein, although splenic arteriovenous shunting secondary to histamine release and increased intrahepatic resistance secondary to mast cell infiltration might have played a role. The portal hypertension was relieved by splenectomy.",

author = "Sharon Grundfest and Cooperman, {Avram M.} and Roy Ferguson and Sanford Benjamin",

year = "1980",

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doi = "10.1016/0016-5085(80)90591-0",

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AU - Grundfest, Sharon

AU - Cooperman, Avram M.

AU - Ferguson, Roy

AU - Benjamin, Sanford

PY - 1980/2

Y1 - 1980/2

N2 - An unusual case of systemic mastocytosis with splenomegaly, portal hypertension, and bleeding esophageal varices is presented. Arteriograms and liver biopsy suggested the mechanism of the portal hypertension was due to increased blood flow in the splenic vein, although splenic arteriovenous shunting secondary to histamine release and increased intrahepatic resistance secondary to mast cell infiltration might have played a role. The portal hypertension was relieved by splenectomy.

AB - An unusual case of systemic mastocytosis with splenomegaly, portal hypertension, and bleeding esophageal varices is presented. Arteriograms and liver biopsy suggested the mechanism of the portal hypertension was due to increased blood flow in the splenic vein, although splenic arteriovenous shunting secondary to histamine release and increased intrahepatic resistance secondary to mast cell infiltration might have played a role. The portal hypertension was relieved by splenectomy.

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DO - 10.1016/0016-5085(80)90591-0

M3 - Article

C2 - 6965282

AN - SCOPUS:0018834602

SN - 0016-5085

VL - 78

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EP - 373

JO - Gastroenterology

JF - Gastroenterology

IS - 2

ER -

Portal hypertension associated with systemic mastocytosis and splenomegaly

Abstract

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