TY - JOUR
T1 - Population attributable fractions for ovarian cancer in Swedish women by morphological type
AU - Granström, C.
AU - Sundquist, J.
AU - Hemminki, K.
N1 - Funding Information:
The Family-Cancer Database was created by linking registers maintained at Statistics Sweden and the Swedish Cancer Registry. The study was supported by Deutsche Krebshilfe, the Swedish Cancer Society, the Swedish Council for Working Life and Social Research and the EU LSHC-CT-2004-503465 Fund.
PY - 2008/1/15
Y1 - 2008/1/15
N2 - Using the Swedish Family-Cancer Database, among a total of 1 030 806 women followed from 1993 through 2004, invasive and borderline epithelial ovarian cancer was identified in 3306 and 822 women respectively, with data on family history, reproductive variables, residential region and socioeconomic status. Relative risks and population-attributable fractions (PAFs) were estimated by Poisson regression. The overall PAFs of invasive epithelial ovarian cancer for family history and for reproductive factors were 2.6 and 22.3%, respectively, for serous/seropapillary cystadenocarcinoma (3.0 and 19.1%), endometrioid carcinoma (2.6 and 26.6%), mucinous cystadenocarcinoma (0.5 and 23.9%) and clear-cell carcinoma (2.6 and 73.9%). The corresponding PAFs of borderline tumours due to family history were lower, but higher due to reproductive factors. Family history, low parity and young age at first birth were associated with elevated risks. The risks for women with a family history were among the highest, but these women accounted for the smallest proportion of the cases, giving the lowest PAFs.
AB - Using the Swedish Family-Cancer Database, among a total of 1 030 806 women followed from 1993 through 2004, invasive and borderline epithelial ovarian cancer was identified in 3306 and 822 women respectively, with data on family history, reproductive variables, residential region and socioeconomic status. Relative risks and population-attributable fractions (PAFs) were estimated by Poisson regression. The overall PAFs of invasive epithelial ovarian cancer for family history and for reproductive factors were 2.6 and 22.3%, respectively, for serous/seropapillary cystadenocarcinoma (3.0 and 19.1%), endometrioid carcinoma (2.6 and 26.6%), mucinous cystadenocarcinoma (0.5 and 23.9%) and clear-cell carcinoma (2.6 and 73.9%). The corresponding PAFs of borderline tumours due to family history were lower, but higher due to reproductive factors. Family history, low parity and young age at first birth were associated with elevated risks. The risks for women with a family history were among the highest, but these women accounted for the smallest proportion of the cases, giving the lowest PAFs.
KW - Family history
KW - Morphological types
KW - Parity
KW - Population-attributable fraction
KW - Relative risk
UR - http://www.scopus.com/inward/record.url?scp=38049019182&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6604135
DO - 10.1038/sj.bjc.6604135
M3 - Article
C2 - 18071361
AN - SCOPUS:38049019182
SN - 0007-0920
VL - 98
SP - 199
EP - 205
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 1
ER -