TY - JOUR
T1 - Pooled Analysis of Alcohol Dehydrogenase Genotypes and Head and Neck Cancer
T2 - A HuGE Review
AU - Brennan, Paul
AU - Lewis, Sarah
AU - Hashibe, Mia
AU - Bell, Douglas A.
AU - Boffetta, Paolo
AU - Bouchardy, Christine
AU - Caporaso, Neil
AU - Chen, Chu
AU - Coutelle, Christiane
AU - Diehl, Scott R.
AU - Hayes, Richard B.
AU - Olshan, Andrew F.
AU - Schwartzs, Stephen M.
AU - Sturgis, Erich M.
AU - Wei, Qingyi
AU - Zavras, Athanasios I.
AU - Benhamou, Simone
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B* 2 and ADH1C* 1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2± 2, results in increased acetylaldehyde levels and is hypothesized to increase the risk of head and neck cancer. To examine this association, the authors undertook a Human Genome Epidemiology review on these three genes and a pooled analysis of published studies on ADH1C. The majority of Asians had the fast ADH1B* 2 and ADH1C* 1 alleles, while the majority of Caucasians had the slow ADH1B* 1/1 and ADH1C* 1/2 genotypes. The ALDH2* 2 null allele was frequently observed among Asians, though it was rarely observed in other populations. In a pooled analysis of data from seven case-control studies with a total of 1,325 cases and 1,760 controls, an increased risk of head and neck cancer was not observed for the ADH1C* 1/2 genotype (odds ratio = 1.00, 95% confidence interval: 0.81, 1.23) or the ADH1C* 1/1 genotype (odds ratio = 1.14, 95% confidence interval: 0.92, 1.41). Increased relative risks of head and neck cancer were reported for the ADH1B* 1/1 and ALDH2* 1/2 genotypes in several studies. Recommendations for future studies include larger sample sizes and incorporation of relevant ADH and ALDH genes simultaneously, as well as other genes. These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field.
AB - Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B* 2 and ADH1C* 1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2± 2, results in increased acetylaldehyde levels and is hypothesized to increase the risk of head and neck cancer. To examine this association, the authors undertook a Human Genome Epidemiology review on these three genes and a pooled analysis of published studies on ADH1C. The majority of Asians had the fast ADH1B* 2 and ADH1C* 1 alleles, while the majority of Caucasians had the slow ADH1B* 1/1 and ADH1C* 1/2 genotypes. The ALDH2* 2 null allele was frequently observed among Asians, though it was rarely observed in other populations. In a pooled analysis of data from seven case-control studies with a total of 1,325 cases and 1,760 controls, an increased risk of head and neck cancer was not observed for the ADH1C* 1/2 genotype (odds ratio = 1.00, 95% confidence interval: 0.81, 1.23) or the ADH1C* 1/1 genotype (odds ratio = 1.14, 95% confidence interval: 0.92, 1.41). Increased relative risks of head and neck cancer were reported for the ADH1B* 1/1 and ALDH2* 1/2 genotypes in several studies. Recommendations for future studies include larger sample sizes and incorporation of relevant ADH and ALDH genes simultaneously, as well as other genes. These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field.
KW - ADH1B
KW - ADH1C
KW - ALDH2
KW - Alcohol dehydrogenase
KW - Aldehyde dehydrogenase
KW - Epidemiology
KW - Genetics
KW - Head and neck neoplasms
UR - http://www.scopus.com/inward/record.url?scp=9144228670&partnerID=8YFLogxK
U2 - 10.1093/aje/kwh003
DO - 10.1093/aje/kwh003
M3 - Review article
C2 - 14693654
AN - SCOPUS:9144228670
SN - 0002-9262
VL - 159
SP - 1
EP - 16
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 1
ER -