TY - CHAP
T1 - Polyomavirus in human cancer development
AU - Lee, Winston
AU - Langhoff, Erik
PY - 2006
Y1 - 2006
N2 - In animal studies, polyoma viruses have been found to be viral agents for oncogenesis and to produce a wide range of pathological lesions in experimental animals, including a variety of neoplastic tumors. The human polyoma viruses (JCV and BKV), along with their simian cousin (SV40), are ubiquitous viruses that are primarily associated with progressive multifocal leukoencephalolopathy (PML) and hemorrhagic cystitis, respectively, under specific conditions in immunocompromized individuals. Currendy, polyoma viruses are now undergoing increasing scrutiny as possible causes for several human cancers. Evidence has been mounting recendy that JCV, BKV as well as SV40 are potential oncogenic viruses in humans as well.
AB - In animal studies, polyoma viruses have been found to be viral agents for oncogenesis and to produce a wide range of pathological lesions in experimental animals, including a variety of neoplastic tumors. The human polyoma viruses (JCV and BKV), along with their simian cousin (SV40), are ubiquitous viruses that are primarily associated with progressive multifocal leukoencephalolopathy (PML) and hemorrhagic cystitis, respectively, under specific conditions in immunocompromized individuals. Currendy, polyoma viruses are now undergoing increasing scrutiny as possible causes for several human cancers. Evidence has been mounting recendy that JCV, BKV as well as SV40 are potential oncogenic viruses in humans as well.
UR - http://www.scopus.com/inward/record.url?scp=33745599672&partnerID=8YFLogxK
U2 - 10.1007/0-387-32957-9_22
DO - 10.1007/0-387-32957-9_22
M3 - Chapter
C2 - 16626045
AN - SCOPUS:33745599672
SN - 9780387292335
T3 - Advances in Experimental Medicine and Biology
SP - 310
EP - 318
BT - Polyomaviruses and Human Diseases
ER -