Abstract
CD4-/- or CD8-/- single knockout as well as CD4-/-8-/double knockout mice were infected with polyoma virus as newborns or 1 week after birth. The animals were followed for tumor development and virus persistence. Double knockout mice developed tumors at a higher incidence (29%) than either the CD8-/- or CD4-/- single knockout mice (11% and 2%, respectively). Persistence of polyoma virus was examined by PCR in one third of all animals included in the study. Seven of the 17 CD4-/-8-/- double knockout mice gave positive evidence of virus persistence up to 6 months p.i. where virus DNA was present in most organs. Corresponding tests in single knockout mice gave positive results of persistent viral DNA in 2 of the 19 CD8-/- and 2 of the 7 CD4-/- mice. In the single knockout mice polyoma DNA could only be detected in a more limited variety of organs compared to the double knockouts.
| Original language | English |
|---|---|
| Pages (from-to) | 405-408 |
| Number of pages | 4 |
| Journal | International Journal of Cancer |
| Volume | 67 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |