TY - JOUR
T1 - Polymorphism screening of four genes encoding advanced glycation end-product putative receptors
T2 - Association study with nephropathy in type 1 diabetic patients
AU - Poirier, Odette
AU - Nicaud, Viviane
AU - Vionnet, Nathalie
AU - Raoux, Ségolène
AU - Tarnow, Lise
AU - Vlassara, Helen
AU - Parving, Hans Henrik
AU - Cambien, François
PY - 2001
Y1 - 2001
N2 - Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy. The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and was associated with a longer duration of nephropathy-free diabetes (P = 0.08).
AB - Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy. The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and was associated with a longer duration of nephropathy-free diabetes (P = 0.08).
UR - https://www.scopus.com/pages/publications/0035029634
U2 - 10.2337/diabetes.50.5.1214
DO - 10.2337/diabetes.50.5.1214
M3 - Article
C2 - 11334430
AN - SCOPUS:0035029634
SN - 0012-1797
VL - 50
SP - 1214
EP - 1218
JO - Diabetes
JF - Diabetes
IS - 5
ER -