TY - JOUR
T1 - Polymethylmethacrylate Collagen Gel-Injectable Dermal Filler for Full Face Atrophic Acne Scar Correction
AU - Joseph, John H.
AU - Shamban, Ava
AU - Eaton, Laura
AU - Lehman, Alayne
AU - Cohen, Steven
AU - Spencer, James
AU - Bruce, Suzanne
AU - Grimes, Pearl
AU - Tedaldi, Ruth
AU - Callender, Valerie
AU - Werschler, Phillip
N1 - Publisher Copyright:
© 2019 by the American Society for Dermatologic Surgery, Inc.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - BACKGROUND/OBJECTIVESThis trial evaluated the effectiveness and safety of Bellafill for full-face acne scar treatment.PATIENTS AND METHODSIn this open-label, nonrandomized, multicenter pilot study investigating the use of polymethylmethacrylate for full-face atrophic acne scar correction, 42 adult subjects with a mean age of 43 years were treated and assessed for safety and effectiveness at Months 4 and 7. There were no hypersensitivity reactions to pretreatment skin testing or during scar treatments.RESULTSAt 4 and 7 months after initial treatment, 92% and 95% of subjects, respectively, were responders with ≥1-point improvement on the 5-point Acne Scar Assessment Scale. Subjects reported very high levels of improvement on the Global Aesthetic Improvement Scale (GAIS), with 95% of subjects reporting "improved or better" at 4 months and 90% at 7 months. The outcome of the physician GAIS was also high with 92% of patients classified as "improved or better" at 4 months and 97% at 7 months. There were only 2 device-related adverse events, both mild events related to Bellafill skin test (bruising, ecchymosis). There were no serious adverse events in response to the treatment product in this short-term follow-up study.CONCLUSIONPolymethylmethacrylate is effective for treating full-face acne scarring. Clinicaltrials.gov #NCT02642627.
AB - BACKGROUND/OBJECTIVESThis trial evaluated the effectiveness and safety of Bellafill for full-face acne scar treatment.PATIENTS AND METHODSIn this open-label, nonrandomized, multicenter pilot study investigating the use of polymethylmethacrylate for full-face atrophic acne scar correction, 42 adult subjects with a mean age of 43 years were treated and assessed for safety and effectiveness at Months 4 and 7. There were no hypersensitivity reactions to pretreatment skin testing or during scar treatments.RESULTSAt 4 and 7 months after initial treatment, 92% and 95% of subjects, respectively, were responders with ≥1-point improvement on the 5-point Acne Scar Assessment Scale. Subjects reported very high levels of improvement on the Global Aesthetic Improvement Scale (GAIS), with 95% of subjects reporting "improved or better" at 4 months and 90% at 7 months. The outcome of the physician GAIS was also high with 92% of patients classified as "improved or better" at 4 months and 97% at 7 months. There were only 2 device-related adverse events, both mild events related to Bellafill skin test (bruising, ecchymosis). There were no serious adverse events in response to the treatment product in this short-term follow-up study.CONCLUSIONPolymethylmethacrylate is effective for treating full-face acne scarring. Clinicaltrials.gov #NCT02642627.
UR - https://www.scopus.com/pages/publications/85075530959
U2 - 10.1097/DSS.0000000000001863
DO - 10.1097/DSS.0000000000001863
M3 - Article
C2 - 30829754
AN - SCOPUS:85075530959
SN - 1076-0512
VL - 45
SP - 1558
EP - 1566
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 12
ER -