Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

Edmund J. Keliher; Yu Xiang Ye; Gregory R. Wojtkiewicz; Aaron D. Aguirre; Benoit Tricot; Max L. Senders; Hannah Groenen; Francois Fay; Carlos Perez-Medina; Claudia Calcagno; Giuseppe Carlucci; Thomas Reiner; Yuan Sun; Gabriel Courties; Yoshiko Iwamoto; Hye Yeong Kim; Cuihua Wang; John W. Chen; Filip K. Swirski; Hsiao Ying Wey; Jacob Hooker; Zahi A. Fayad; Willem J.M. Mulder; Ralph Weissleder; Matthias Nahrendorf

doi:10.1038/ncomms14064

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

Edmund J. Keliher
, Yu Xiang Ye
, Gregory R. Wojtkiewicz
, Aaron D. Aguirre
, Benoit Tricot
, Max L. Senders
, Hannah Groenen
, Francois Fay
, Carlos Perez-Medina
, Claudia Calcagno
, Giuseppe Carlucci
, Thomas Reiner
, Yuan Sun
, Gabriel Courties
, Yoshiko Iwamoto
, Hye Yeong Kim
, Cuihua Wang
, John W. Chen
, Filip K. Swirski
, Hsiao Ying Wey

Jacob Hooker, Zahi A. Fayad, Willem J.M. Mulder, Ralph Weissleder, Matthias Nahrendorf

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with 18 F-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18. The particle's short blood half-life, measured in three species, including a primate, enables macrophage imaging in inflamed cardiovascular tissues. Macroflor enriches in cardiac and plaque macrophages, thereby increasing PET signal in murine infarcts and both mouse and rabbit atherosclerotic plaques. In PET/magnetic resonance imaging (MRI) experiments, Macroflor PET imaging detects changes in macrophage population size while molecular MRI reports on increasing or resolving inflammation. These data suggest that Macroflor PET/MRI could be a clinical tool to non-invasively monitor macrophage biology.

Original language	English
Article number	14064
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms14064
State	Published - 16 Jan 2017

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Keliher, E. J., Ye, Y. X., Wojtkiewicz, G. R., Aguirre, A. D., Tricot, B., Senders, M. L., Groenen, H., Fay, F., Perez-Medina, C., Calcagno, C., Carlucci, G., Reiner, T., Sun, Y., Courties, G., Iwamoto, Y., Kim, H. Y., Wang, C., Chen, J. W., Swirski, F. K., ... Nahrendorf, M. (2017). Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nature Communications, 8, Article 14064. https://doi.org/10.1038/ncomms14064

@article{aca8977a83174a3fbddf8179f98fe692,

title = "Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease",

abstract = "Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with 18 F-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18. The particle's short blood half-life, measured in three species, including a primate, enables macrophage imaging in inflamed cardiovascular tissues. Macroflor enriches in cardiac and plaque macrophages, thereby increasing PET signal in murine infarcts and both mouse and rabbit atherosclerotic plaques. In PET/magnetic resonance imaging (MRI) experiments, Macroflor PET imaging detects changes in macrophage population size while molecular MRI reports on increasing or resolving inflammation. These data suggest that Macroflor PET/MRI could be a clinical tool to non-invasively monitor macrophage biology.",

author = "Keliher, \{Edmund J.\} and Ye, \{Yu Xiang\} and Wojtkiewicz, \{Gregory R.\} and Aguirre, \{Aaron D.\} and Benoit Tricot and Senders, \{Max L.\} and Hannah Groenen and Francois Fay and Carlos Perez-Medina and Claudia Calcagno and Giuseppe Carlucci and Thomas Reiner and Yuan Sun and Gabriel Courties and Yoshiko Iwamoto and Kim, \{Hye Yeong\} and Cuihua Wang and Chen, \{John W.\} and Swirski, \{Filip K.\} and Wey, \{Hsiao Ying\} and Jacob Hooker and Fayad, \{Zahi A.\} and Mulder, \{Willem J.M.\} and Ralph Weissleder and Matthias Nahrendorf",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = jan,

day = "16",

doi = "10.1038/ncomms14064",

language = "English",

volume = "8",

journal = "Nature Communications",

issn = "2041-1723",

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Keliher, EJ, Ye, YX, Wojtkiewicz, GR, Aguirre, AD, Tricot, B, Senders, ML, Groenen, H, Fay, F, Perez-Medina, C, Calcagno, C, Carlucci, G, Reiner, T, Sun, Y, Courties, G, Iwamoto, Y, Kim, HY, Wang, C, Chen, JW, Swirski, FK, Wey, HY, Hooker, J, Fayad, ZA , Mulder, WJM, Weissleder, R & Nahrendorf, M 2017, 'Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease', Nature Communications, vol. 8, 14064. https://doi.org/10.1038/ncomms14064

TY - JOUR

T1 - Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

AU - Keliher, Edmund J.

AU - Ye, Yu Xiang

AU - Wojtkiewicz, Gregory R.

AU - Aguirre, Aaron D.

AU - Tricot, Benoit

AU - Senders, Max L.

AU - Groenen, Hannah

AU - Fay, Francois

AU - Perez-Medina, Carlos

AU - Calcagno, Claudia

AU - Carlucci, Giuseppe

AU - Reiner, Thomas

AU - Sun, Yuan

AU - Courties, Gabriel

AU - Iwamoto, Yoshiko

AU - Kim, Hye Yeong

AU - Wang, Cuihua

AU - Chen, John W.

AU - Swirski, Filip K.

AU - Wey, Hsiao Ying

AU - Hooker, Jacob

AU - Fayad, Zahi A.

AU - Mulder, Willem J.M.

AU - Weissleder, Ralph

AU - Nahrendorf, Matthias

PY - 2017/1/16

Y1 - 2017/1/16

N2 - Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with 18 F-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18. The particle's short blood half-life, measured in three species, including a primate, enables macrophage imaging in inflamed cardiovascular tissues. Macroflor enriches in cardiac and plaque macrophages, thereby increasing PET signal in murine infarcts and both mouse and rabbit atherosclerotic plaques. In PET/magnetic resonance imaging (MRI) experiments, Macroflor PET imaging detects changes in macrophage population size while molecular MRI reports on increasing or resolving inflammation. These data suggest that Macroflor PET/MRI could be a clinical tool to non-invasively monitor macrophage biology.

AB - Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring macrophages in patients. Here we describe positron emission tomography (PET) imaging with 18 F-Macroflor, a modified polyglucose nanoparticle with high avidity for macrophages. Due to its small size, Macroflor is excreted renally, a prerequisite for imaging with the isotope flourine-18. The particle's short blood half-life, measured in three species, including a primate, enables macrophage imaging in inflamed cardiovascular tissues. Macroflor enriches in cardiac and plaque macrophages, thereby increasing PET signal in murine infarcts and both mouse and rabbit atherosclerotic plaques. In PET/magnetic resonance imaging (MRI) experiments, Macroflor PET imaging detects changes in macrophage population size while molecular MRI reports on increasing or resolving inflammation. These data suggest that Macroflor PET/MRI could be a clinical tool to non-invasively monitor macrophage biology.

UR - https://www.scopus.com/pages/publications/85009494373

U2 - 10.1038/ncomms14064

DO - 10.1038/ncomms14064

M3 - Article

C2 - 28091604

AN - SCOPUS:85009494373

SN - 2041-1723

VL - 8

JO - Nature Communications

JF - Nature Communications

M1 - 14064

ER -

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

Abstract

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