Polycystic ovary syndrome: Clinical perspectives and management

Walter Futterweit

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


The polycystic ovary syndrome (PCOS) is a common hyperandrogenic disorder and is characterized by a constellation of signs and symptoms often in association with a family history of hyperandrogenism and/or PCOS. It is often associated with hyperinsulinism and insulin resistance, which puts patients at risk for possible potential complications including type 2 diabetes mellitus and cardiovascular disease. Clinical signs may be subtle, and biochemical markers most often include an elevation of free testosterone (T) and possibly dehydroepiandrosterone sulfate (DHEAS). The diagnosis should be sought in any woman with hyperandrogenic features so that appropriate treatment may be used. There is often a good therapeutic response of the hirsutism, acne, or oligomenorrhea associated with PCOS. The new modalities that increase insulin sensitivity as well as weight reduction in the obese woman with PCOS may potentially be useful in modifying the potential later complications of this common endocrinopathy of young adult women. Target Audience: Obstetricians and Gynecologists, Family Physicians. Learning Objectives: After completion of this article, the reader will be able to understand the clinical signs, symptoms, and associated conditions of a patient with polycystic ovary syndrome, and the appropriate work-up and therapeutic options for a PCO patient.

Original languageEnglish
Pages (from-to)403-413
Number of pages11
JournalObstetrical and Gynecological Survey
Issue number6
StatePublished - Jun 1999


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