Polycystic Ovarian Syndrome: Long-Term Health Consequences

Temeka Zore, Nikhil V. Joshi, Daria Lizneva, Ricardo Azziz

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy in women and can be associated with significant adverse sequelae that can affect overall long-term health and well-being. This review provides a succinct but comprehensive overview of our current understanding concerning the known morbidities of PCOS, beginning with a review of the importance of the different phenotypes of PCOS in determining long-term morbidity, the confounding impact of obesity on health outcomes in PCOS, and the immediate short-term consequences of the disorder (including dermatologic, reproductive, and mood disturbances). The longer-term morbidities of PCOS are then reviewed including metabolic consequences (impaired glucose tolerance and type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease), dyslipidemia and vascular dysfunction (including hypertension and increased incidences of cerebrovascular accidents and thromboembolisms on oral contraceptives), neoplastic (primarily endometrial adenocarcinoma), and mental health disorders (including greater incidences of depressive and anxiety disturbances and psychosexual dysfunction). In conclusion, strategies for the prevention and amelioration of long-term morbidities in PCOS are presented.

Original languageEnglish
Pages (from-to)271-281
Number of pages11
JournalSeminars in Reproductive Medicine
Issue number3
StatePublished - 1 May 2017
Externally publishedYes


  • anxiety
  • breast cancer
  • cardiovascular disease
  • depression
  • endometrial adenocarcinoma
  • health consequences
  • hypertension
  • metabolic dysfunction
  • polycystic ovarian syndrome
  • type 2 diabetes mellitus


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