Polycyclic Aromatic Hydrocarbon–DNA Adducts and Breast Cancer: A Pooled Analysis

Marilie D. Gammon, Sharon K. Sagiv, Sybil M. Eng, Sumitra Shantakumar, Mia M. Gaudet, Susan L. Teitelbaum, Julie A. Britton, Mary Beth Terry, Lian Wen Wang, Qiao Wang, Steve D. Stellman, Jan Beyea, Maureen Hatch, Geoffrey C. Kabat, Mary S. Wolff, Bruce Levin, Alfred I. Neugut, Regina M. Santella

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88 Scopus citations


Polycyclic aromatic hydrocarbon (PAH)-DNA adducts have been associated with breast cancer in several small studies. The authors' pooled analysis included 873 cases and 941 controls from a population-based case-control study. Competitive enzyme-linked immunosorbent assay in peripheral mononuclear cells was conducted in 2 rounds, and results were pooled on the basis of round-specific quantiles. The odds ratio for breast cancer was elevated in relation to detectable PAH-DNA adducts (1.29 as compared with non-detectable adduct levels; 95% confidence interval = 1.05, 1.58), but there was no apparent dose-response relationship with increasing quantiles. No consistent pattern emerged when the results were stratified by PAH sources (e.g., active cigarette smoking or PAH-containing foods), or when the cases were categorized by stage of disease or hormone receptor status. These data provide only modest support for an association between PAH-DNA adducts and breast cancer development.

Original languageEnglish
Pages (from-to)640-649
Number of pages10
JournalArchives of Environmental Health
Issue number12
StatePublished - Dec 2004


  • Air pollution
  • Breast cancer
  • Cigarette smoking
  • Cooked meat
  • Dma adducts
  • Passive smoking
  • Polycyclic aromatic hydrocarbons


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