@article{11d9a3e4c27d46319702853e4a8dc46a,
title = "Polycyclic Aromatic Hydrocarbon–DNA Adducts and Breast Cancer: A Pooled Analysis",
abstract = "Polycyclic aromatic hydrocarbon (PAH)-DNA adducts have been associated with breast cancer in several small studies. The authors' pooled analysis included 873 cases and 941 controls from a population-based case-control study. Competitive enzyme-linked immunosorbent assay in peripheral mononuclear cells was conducted in 2 rounds, and results were pooled on the basis of round-specific quantiles. The odds ratio for breast cancer was elevated in relation to detectable PAH-DNA adducts (1.29 as compared with non-detectable adduct levels; 95% confidence interval = 1.05, 1.58), but there was no apparent dose-response relationship with increasing quantiles. No consistent pattern emerged when the results were stratified by PAH sources (e.g., active cigarette smoking or PAH-containing foods), or when the cases were categorized by stage of disease or hormone receptor status. These data provide only modest support for an association between PAH-DNA adducts and breast cancer development.",
keywords = "Air pollution, Breast cancer, Cigarette smoking, Cooked meat, Dma adducts, Passive smoking, Polycyclic aromatic hydrocarbons",
author = "Gammon, {Marilie D.} and Sagiv, {Sharon K.} and Eng, {Sybil M.} and Sumitra Shantakumar and Gaudet, {Mia M.} and Teitelbaum, {Susan L.} and Britton, {Julie A.} and Terry, {Mary Beth} and Wang, {Lian Wen} and Qiao Wang and Stellman, {Steve D.} and Jan Beyea and Maureen Hatch and Kabat, {Geoffrey C.} and Wolff, {Mary S.} and Bruce Levin and Neugut, {Alfred I.} and Santella, {Regina M.}",
note = "Funding Information: For their valuable contributions to the Long Island Breast Cancer Study Project, the authors thank the members of the Long Island Breast Cancer Network; the 31 participating institutions on Long Island and in New York City, NY; our National Institutes of Health collaborators-Gwen Colman, Ph.D., National Institutes of Environmental Health Sciences; G. Iris Obrams, M.D., Ph.D. formerly of the National Cancer Institute; members of the External Advisory Committee to the population-based case-control study Leslie Bernstein, Ph.D. (committee chair); Gerald Akland, M.S.; Barbara Balaban, M.S.W.; Blake Cady, M.D.; Dale Sandler, Ph.D.; Roy Shore, Ph.D.; and Gerald Wogan, Ph.D., as well as other collaborators who assisted with various aspects of our data collection efforts, including Gail Garbowski, M.P.H.; H. Leon Bradlow, Ph.D.; David Camann, 6.5; Martin Trent, 6.5; Ruby Senie, Ph.D.; Carla Maffeo, Ph.D.; Pat Montalvan; Gertrud Berkowitz, Ph.D.; Margaret Kemeny, M.D.; Mark Citron, M.D.; Freya Schnabel, M.D.; Allen Schuss, M.D.; Steven Hajdu, M.D.; and Vincent Vinceguerra, M.D. This work was supported in part by grants from the National Cancer Institute and the National Institutes of Environmental Health and Sciences (grants UO1 CNES66572, UO1 CA66572, P30ES09089, and P30ES101261, the Breast Cancer Research Foundation, and the Babylon Breast Cancer Coalition. Submitted for publication October 28, 2003; revised; accepted for publication May 14, 2004. Requests for reprints should be sent to Dr. Marilie D. Gammon, Department of Epidemiology, CB#7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, NC 27599-7435. E-mail: gammon@unc.edu Copyright 0 2006 Heldref Publications",
year = "2004",
month = dec,
doi = "10.1080/00039890409602948",
language = "English",
volume = "59",
pages = "640--649",
journal = "Archives of Environmental and Occupational Health",
issn = "1933-8244",
publisher = "Heldref Publications",
number = "12",
}