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Polycomb Proteins and their Roles in Skin Development and Regeneration

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Polycomb repressive complexes (PRC) are essential chromatin regulators that control tissue development and stem cells. While studies have revealed the functions of Polycomb proteins in embryonic stem cells and mammalian tissues, the exact mechanisms of Polycomb function largely remain to be elucidated. Here, we will discuss evidence of the essential roles of Polycomb proteins in the skin, including their roles in the control of development, wound healing and regeneration, as well as in triggering common skin diseases, including cancer and psoriasis.

Original languageEnglish
Title of host publicationStem Cell Biology and Regenerative Medicine
PublisherSpringer Nature
Pages75-104
Number of pages30
DOIs
StatePublished - 2018

Publication series

NameStem Cell Biology and Regenerative Medicine
VolumePart F4882
ISSN (Print)2196-8985
ISSN (Electronic)2196-8993

Keywords

  • Embryonic SC (ESCs)
  • Epidermal Differentiation Genes
  • Merkel Cell
  • Polycomb Repressive Complex 2 (PRC1)
  • PRC1 Complexes

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