Maternal MTHFR polymorphisms and risk of spontaneous abortion

Translated title of the contribution: Maternal MTHFR polymorphisms and risk of spontaneous abortion

María del Rosario Rodríguez-Guillén, Luisa Torres-Sánchez, Jia Chen, Marcia Galván-Portillo, Julia Blanco-Muñoz, Miriam Aracely Anaya, Irma Silva-Zolezzi, María A. Hernández-Valero, Lizbeth López-Carrillo

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objective: To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C). Material and Methods: We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with SA were compared to 74 women whose pregnancy survived beyond week 20th. Intake of folate and B vitamins respectively, was estimated using a validated food frequency questionnaire. Maternal MTHFR polymorphisms were determined by PCR-RFLP and serum homocysteine levels by HPLC. Results: Carriers of MTHFR 677TT and 1298AC genotypes respectively showed an increased risk of SA (OR 677TT vs. CC/CT=5.0; 95% CI: 1.2, 20.9 and OR 1298 AC vs. AA=5.5; 95% CI: 1.1, 26.6). Conclusions: Our results support the role of MTHFR polymorphisms as a risk factor for SA, regardless of dietary intake of B vitamins.

Translated title of the contributionMaternal MTHFR polymorphisms and risk of spontaneous abortion
Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalSalud Publica de Mexico
Issue number1
StatePublished - 2009


  • 677 C>T and 1298 A>C polymorphisms
  • Mexico
  • Spontaneous abortion


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