Podocyte as the link between sterile inflammation and diabetic kidney disease

Emelie Lassén, Rihab Bouchareb, Ilse S. Daehn

Research output: Contribution to journalComment/debate

3 Scopus citations


Shahzad et al. examined the underlying mechanisms of sterile inflammation in diabetic kidney disease, specifically the role of NLRP3 inflammasome activation in podocytes. Using mouse models with gain-of-function and loss-of-function mutations in podocyte Nlrp3, or caspase-1 loss-of-function mutations in podocytes, they identified that Nlrp3 activation in these cells is central for development of diabetic kidney disease but not solely dependent on canonical mechanisms and caspase-1. These findings position podocyte-mediated immune cell-like functions as potential therapeutic targets for diabetic kidney disease.

Original languageEnglish
Pages (from-to)688-690
Number of pages3
JournalKidney International
Issue number4
StatePublished - Oct 2022


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