Pneumonitis in human cytomegalovirus infection

Erik Langhoff; Robert E. Siegel

doi:10.1007/s11908-006-0063-z

Pneumonitis in human cytomegalovirus infection

Erik Langhoff, Robert E. Siegel

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Human cytomegalovirus (HCMV) is a β herpes virus with a double stranded DNA genome of 240kbp. The virus is prevalent and establishes a latent infection in most adults. HCMV is an opportunistic pathogen for patients with impaired cellular immunity. HCMV pneumonia is a common presentation of HCMV disease in immunocompromised patients. The incidence of HCMV pneumonitis can be as high as 90% in lung transplant recipients. This paper takes a fresh look at the challenging perspectives of molecular, immunologic, cellular, diagnostic, clinical, and therapeutic characteristics of HCMV infection as future targets for development of antiviral strategies.

Original language	English
Pages (from-to)	222-230
Number of pages	9
Journal	Current Infectious Disease Reports
Volume	8
Issue number	3
DOIs	https://doi.org/10.1007/s11908-006-0063-z
State	Published - May 2006
Externally published	Yes

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abstract = "Human cytomegalovirus (HCMV) is a β herpes virus with a double stranded DNA genome of 240kbp. The virus is prevalent and establishes a latent infection in most adults. HCMV is an opportunistic pathogen for patients with impaired cellular immunity. HCMV pneumonia is a common presentation of HCMV disease in immunocompromised patients. The incidence of HCMV pneumonitis can be as high as 90% in lung transplant recipients. This paper takes a fresh look at the challenging perspectives of molecular, immunologic, cellular, diagnostic, clinical, and therapeutic characteristics of HCMV infection as future targets for development of antiviral strategies.",

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Pneumonitis in human cytomegalovirus infection

Abstract

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