Pluripotent stem cell-derived dopaminergic neurons as models of neurodegeneration

Bradley Watmuff; Brigham Jay Hartley; Cameron Philip Hunt; Colin William Pouton; John Michael Haynes

doi:10.2217/fnl.13.50

Pluripotent stem cell-derived dopaminergic neurons as models of neurodegeneration

Bradley Watmuff, Brigham Jay Hartley, Cameron Philip Hunt, Colin William Pouton, John Michael Haynes

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Researchers utilize a number of models of Parkinson"s disease ranging in complexity from immortalized cell lines to nonhuman primates. These models are used to investigate everything from the mechanisms underlying neurodegeneration, to drugs that may improve patient outcomes. Each model system has advantages and disadvantages, depending on their application. In this review, the authors assess the potential value of embryonic stem and induced-pluripotent stem cells as additions to the crowded Parkinson"s disease in vitro model landscape.

Original language	English
Pages (from-to)	649-661
Number of pages	13
Journal	Future Neurology
Volume	8
Issue number	6
DOIs	https://doi.org/10.2217/fnl.13.50
State	Published - Nov 2013
Externally published	Yes

Keywords

Parkinson"s disease
embryonic stem cells
induced pluripotent stem cells
model
neurodegeneration

Access to Document

10.2217/fnl.13.50

Cite this

@article{90109abcfb30424bb24cf1ad203de9c4,

title = "Pluripotent stem cell-derived dopaminergic neurons as models of neurodegeneration",

abstract = "Researchers utilize a number of models of Parkinson{"}s disease ranging in complexity from immortalized cell lines to nonhuman primates. These models are used to investigate everything from the mechanisms underlying neurodegeneration, to drugs that may improve patient outcomes. Each model system has advantages and disadvantages, depending on their application. In this review, the authors assess the potential value of embryonic stem and induced-pluripotent stem cells as additions to the crowded Parkinson{"}s disease in vitro model landscape.",

keywords = "Parkinson{"}s disease, embryonic stem cells, induced pluripotent stem cells, model, neurodegeneration",

author = "Bradley Watmuff and Hartley, {Brigham Jay} and Hunt, {Cameron Philip} and Pouton, {Colin William} and Haynes, {John Michael}",

year = "2013",

month = nov,

doi = "10.2217/fnl.13.50",

language = "English",

volume = "8",

pages = "649--661",

journal = "Future Neurology",

issn = "1479-6708",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - Pluripotent stem cell-derived dopaminergic neurons as models of neurodegeneration

AU - Watmuff, Bradley

AU - Hartley, Brigham Jay

AU - Hunt, Cameron Philip

AU - Pouton, Colin William

AU - Haynes, John Michael

PY - 2013/11

Y1 - 2013/11

N2 - Researchers utilize a number of models of Parkinson"s disease ranging in complexity from immortalized cell lines to nonhuman primates. These models are used to investigate everything from the mechanisms underlying neurodegeneration, to drugs that may improve patient outcomes. Each model system has advantages and disadvantages, depending on their application. In this review, the authors assess the potential value of embryonic stem and induced-pluripotent stem cells as additions to the crowded Parkinson"s disease in vitro model landscape.

AB - Researchers utilize a number of models of Parkinson"s disease ranging in complexity from immortalized cell lines to nonhuman primates. These models are used to investigate everything from the mechanisms underlying neurodegeneration, to drugs that may improve patient outcomes. Each model system has advantages and disadvantages, depending on their application. In this review, the authors assess the potential value of embryonic stem and induced-pluripotent stem cells as additions to the crowded Parkinson"s disease in vitro model landscape.

KW - Parkinson"s disease

KW - embryonic stem cells

KW - induced pluripotent stem cells

KW - model

KW - neurodegeneration

UR - http://www.scopus.com/inward/record.url?scp=84887246624&partnerID=8YFLogxK

U2 - 10.2217/fnl.13.50

DO - 10.2217/fnl.13.50

M3 - Review article

AN - SCOPUS:84887246624

SN - 1479-6708

VL - 8

SP - 649

EP - 661

JO - Future Neurology

JF - Future Neurology

IS - 6

ER -

Pluripotent stem cell-derived dopaminergic neurons as models of neurodegeneration

Abstract

Keywords

Access to Document

Fingerprint

Cite this