Pluripotent stem cell-derived dopaminergic neurons as models of neurodegeneration

Bradley Watmuff, Brigham Jay Hartley, Cameron Philip Hunt, Colin William Pouton, John Michael Haynes

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Researchers utilize a number of models of Parkinson"s disease ranging in complexity from immortalized cell lines to nonhuman primates. These models are used to investigate everything from the mechanisms underlying neurodegeneration, to drugs that may improve patient outcomes. Each model system has advantages and disadvantages, depending on their application. In this review, the authors assess the potential value of embryonic stem and induced-pluripotent stem cells as additions to the crowded Parkinson"s disease in vitro model landscape.

Original languageEnglish
Pages (from-to)649-661
Number of pages13
JournalFuture Neurology
Issue number6
StatePublished - Nov 2013
Externally publishedYes


  • Parkinson"s disease
  • embryonic stem cells
  • induced pluripotent stem cells
  • model
  • neurodegeneration


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