Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance

Alexander M. Real; William M. Marsiglia; Arvin C. Dar

doi:10.1016/j.chembiol.2020.06.019

Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance

Alexander M. Real, William M. Marsiglia, Arvin C. Dar

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

In this issue of Cell Chemical Biology, Pisa et al. (2020) find that haploid and diploid cells differentially develop resistance to the CENP-E inhibitor GSK923295. The results highlight the power of tumor cells to evade growth inhibition and potentially inform the design of next-generation CENP-E drugs to overcome resistance.

Original language	English
Pages (from-to)	770-772
Number of pages	3
Journal	Cell Chemical Biology
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/j.chembiol.2020.06.019
State	Published - 16 Jul 2020

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title = "Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance",

abstract = "In this issue of Cell Chemical Biology, Pisa et al. (2020) find that haploid and diploid cells differentially develop resistance to the CENP-E inhibitor GSK923295. The results highlight the power of tumor cells to evade growth inhibition and potentially inform the design of next-generation CENP-E drugs to overcome resistance.",

author = "Real, {Alexander M.} and Marsiglia, {William M.} and Dar, {Arvin C.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

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T1 - Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance

AU - Real, Alexander M.

AU - Marsiglia, William M.

AU - Dar, Arvin C.

PY - 2020/7/16

Y1 - 2020/7/16

N2 - In this issue of Cell Chemical Biology, Pisa et al. (2020) find that haploid and diploid cells differentially develop resistance to the CENP-E inhibitor GSK923295. The results highlight the power of tumor cells to evade growth inhibition and potentially inform the design of next-generation CENP-E drugs to overcome resistance.

AB - In this issue of Cell Chemical Biology, Pisa et al. (2020) find that haploid and diploid cells differentially develop resistance to the CENP-E inhibitor GSK923295. The results highlight the power of tumor cells to evade growth inhibition and potentially inform the design of next-generation CENP-E drugs to overcome resistance.

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U2 - 10.1016/j.chembiol.2020.06.019

DO - 10.1016/j.chembiol.2020.06.019

M3 - Comment/debate

C2 - 32679092

AN - SCOPUS:85087781928

SN - 2451-9448

VL - 27

SP - 770

EP - 772

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 7

ER -

Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance

Abstract

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