Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125

Kevin Holcomb, Michelle Francis, Jose Ruiz, Ovadia Abulafia, Roland P. Matthews, Yi Chun Lee

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background. Pure rhabdomyosarcoma of the uterus is an exceedingly rare tumor, While there are no commonly associated tumor markers, a previously reported case confirmed CA125 production by a pure uterine rhabdomyosarcoma. Case. We describe a postmenopausal woman who presented with vaginal bleeding and was diagnosed with pleomorphic rhabdomyosarcoma of the uterus. Of particular interest was an elevated serum CA125 level at presentation. Immunohistochemical staining with CA125 antibody, however, showed no activity within the tumor. Despite aggressive therapy, the patient experienced distant nodal metastases and succumbed to the disease within 25 months of diagnosis. Conclusion. Our patient illustrates the typical presentation and aggressive behavior of this rare neoplasm. While serum CA125 may be a useful tumor marker in selected patients, elevated levels do not directly reflect tumor burden when associated with negative immunohistochemical staining.

Original languageEnglish
Pages (from-to)499-501
Number of pages3
JournalGynecologic Oncology
Issue number3
StatePublished - Sep 1999
Externally publishedYes


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