TY - JOUR
T1 - PLC-α
T2 - A common mediator of the action of estrogen and other hormones?
AU - Mobbs, C. V.
AU - Kaplitt, M.
AU - Kow, L. M.
AU - Pfaff, D. W.
N1 - Funding Information:
This work has been supported by NIH grant PHS HD25543. C.V.M. is a Glenn Foundation Fellow. We would like to thank S. Kleopoulos, U. Olazabal and J. Pfauss for ongoing contributions to this work, C.F. Bennett for reagents, and P.W. Majerus for helpful discussions.
PY - 1991/9
Y1 - 1991/9
N2 - The phosphatidyl inositol (PI) second messenger pathway may mediate diverse effects of estrogen, including its potentiation of the effects of other hormones. Both estradiol (E2) and luteinizing hormone-releasing hormone (LHRH) induce a putative isoform of PI-specific phospholipase C-α (PLC-α). PLC-α catalyzes PI hydrolysis, which in turn can increase protein kinase C (PKC) activation, Ca2+ mobilization, and arachidonic acid metabolism. Estrogen activates the PI pathway, and components of the PI pathway can mimic or enhance some effects of estrogen. Furthermore, estrogen potentiates effects of several hormones (e.g., LHRH, prolactin, and insulin) which can also act through the PI system. PLC-α may therefore provide a common second messenger pathway mediating the potentiation by E2 of the effects of other hormones; in addition it may also mediate some or all of the many actions of E2, since components of the PI pathway can have secretory, trophic, toxic, and neuromodulatory effects.
AB - The phosphatidyl inositol (PI) second messenger pathway may mediate diverse effects of estrogen, including its potentiation of the effects of other hormones. Both estradiol (E2) and luteinizing hormone-releasing hormone (LHRH) induce a putative isoform of PI-specific phospholipase C-α (PLC-α). PLC-α catalyzes PI hydrolysis, which in turn can increase protein kinase C (PKC) activation, Ca2+ mobilization, and arachidonic acid metabolism. Estrogen activates the PI pathway, and components of the PI pathway can mimic or enhance some effects of estrogen. Furthermore, estrogen potentiates effects of several hormones (e.g., LHRH, prolactin, and insulin) which can also act through the PI system. PLC-α may therefore provide a common second messenger pathway mediating the potentiation by E2 of the effects of other hormones; in addition it may also mediate some or all of the many actions of E2, since components of the PI pathway can have secretory, trophic, toxic, and neuromodulatory effects.
KW - HIP-70
KW - Phosphatidyl inositol
KW - Protein kinase C
KW - Reproductive
KW - Second messenger
UR - http://www.scopus.com/inward/record.url?scp=0025800131&partnerID=8YFLogxK
U2 - 10.1016/0303-7207(91)90136-G
DO - 10.1016/0303-7207(91)90136-G
M3 - Article
C2 - 1955069
AN - SCOPUS:0025800131
SN - 0303-7207
VL - 80
SP - C187-C191
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-3
ER -