Platelet [3H]Imipramine binding in psychiatric disorders

Philip D. Kanof, Emil F. Coccaro, Celeste A. Johns, Larry J. Siever, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The Bmax and Kd values for [3H]imipramine binding were measured in platelets from drug-free normal controls and schizophrenic and depressive patients. No differences among groups were found. Exacerbated and remitted patients with either schizophrenia or depression did not differ in platelet [3H]imipramine binding parameters. No correlations were observed between platelet [3H]imipramine binding parameters and measures of symptom severity among actively ill patients with either schizophrenia or depression.

Original languageEnglish
Pages (from-to)278-286
Number of pages9
JournalBiological Psychiatry
Volume22
Issue number3
DOIs
StatePublished - Mar 1987

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