Platelet MAO activity and psychosis proneness in college students

Rachel Yehuda; William S. Edell; Jerrold S. Meyer

doi:10.1016/0165-1781(87)90005-9

Platelet MAO activity and psychosis proneness in college students

Rachel Yehuda, William S. Edell, Jerrold S. Meyer

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A population of individuals potentially at risk for psychiatric disorders was identified by screening 633 college students using the Wisconsin Scales for psychosis proneness. Platelet monoamine oxidase (MAO) activity was measured in high-scoring individuals and controls using ¹⁴C-benzylamine. Males with deviant scores on the Perceptual Aberration-Magical Ideation Scale showed a bimodal distribution of platelet MAO activity. Kinetic analysis of platelet from probands with the highest and lowest levels of MAO activity in this group revealed differences in V_max but not in K_m. Since abnormal platelet MAO activity has been linked to psychiatric vulnerability, the results provide further support for the validity of the Wisconsin Scales as predictors of psychopathology.

Original language	English
Pages (from-to)	129-142
Number of pages	14
Journal	Psychiatry Research
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(87)90005-9
State	Published - Feb 1987

Keywords

Platelet monoamine oxidase
high-risk strategy
psychosis
psychosis proneness

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10.1016/0165-1781(87)90005-9

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title = "Platelet MAO activity and psychosis proneness in college students",

abstract = "A population of individuals potentially at risk for psychiatric disorders was identified by screening 633 college students using the Wisconsin Scales for psychosis proneness. Platelet monoamine oxidase (MAO) activity was measured in high-scoring individuals and controls using 14C-benzylamine. Males with deviant scores on the Perceptual Aberration-Magical Ideation Scale showed a bimodal distribution of platelet MAO activity. Kinetic analysis of platelet from probands with the highest and lowest levels of MAO activity in this group revealed differences in Vmax but not in Km. Since abnormal platelet MAO activity has been linked to psychiatric vulnerability, the results provide further support for the validity of the Wisconsin Scales as predictors of psychopathology.",

keywords = "Platelet monoamine oxidase, high-risk strategy, psychosis, psychosis proneness",

author = "Rachel Yehuda and Edell, \{William S.\} and Meyer, \{Jerrold S.\}",

note = "Funding Information: Acknowledgment. The research reported was supported in part by a Sigma Xi Grant-in-Aid (R.Y.), Faculty Research Grant 2-03074( W.S.E.), and National Science Foundation Grant BNS-81 18073( J.S.M.).",

year = "1987",

month = feb,

doi = "10.1016/0165-1781(87)90005-9",

language = "English",

volume = "20",

pages = "129--142",

journal = "Psychiatry Research",

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T1 - Platelet MAO activity and psychosis proneness in college students

AU - Yehuda, Rachel

AU - Edell, William S.

AU - Meyer, Jerrold S.

N1 - Funding Information: Acknowledgment. The research reported was supported in part by a Sigma Xi Grant-in-Aid (R.Y.), Faculty Research Grant 2-03074( W.S.E.), and National Science Foundation Grant BNS-81 18073( J.S.M.).

PY - 1987/2

Y1 - 1987/2

N2 - A population of individuals potentially at risk for psychiatric disorders was identified by screening 633 college students using the Wisconsin Scales for psychosis proneness. Platelet monoamine oxidase (MAO) activity was measured in high-scoring individuals and controls using 14C-benzylamine. Males with deviant scores on the Perceptual Aberration-Magical Ideation Scale showed a bimodal distribution of platelet MAO activity. Kinetic analysis of platelet from probands with the highest and lowest levels of MAO activity in this group revealed differences in Vmax but not in Km. Since abnormal platelet MAO activity has been linked to psychiatric vulnerability, the results provide further support for the validity of the Wisconsin Scales as predictors of psychopathology.

AB - A population of individuals potentially at risk for psychiatric disorders was identified by screening 633 college students using the Wisconsin Scales for psychosis proneness. Platelet monoamine oxidase (MAO) activity was measured in high-scoring individuals and controls using 14C-benzylamine. Males with deviant scores on the Perceptual Aberration-Magical Ideation Scale showed a bimodal distribution of platelet MAO activity. Kinetic analysis of platelet from probands with the highest and lowest levels of MAO activity in this group revealed differences in Vmax but not in Km. Since abnormal platelet MAO activity has been linked to psychiatric vulnerability, the results provide further support for the validity of the Wisconsin Scales as predictors of psychopathology.

KW - Platelet monoamine oxidase

KW - high-risk strategy

KW - psychosis

KW - psychosis proneness

UR - https://www.scopus.com/pages/publications/0023141462

U2 - 10.1016/0165-1781(87)90005-9

DO - 10.1016/0165-1781(87)90005-9

M3 - Article

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AN - SCOPUS:0023141462

SN - 0165-1781

VL - 20

SP - 129

EP - 142

JO - Psychiatry Research

JF - Psychiatry Research

IS - 2

ER -

Platelet MAO activity and psychosis proneness in college students

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Keywords

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