Platelet-derived growth factor system in human oncogenesis and its signaling pathways

T. Matsui

Research output: Contribution to journalArticlepeer-review


v-sis represents a prototype of the class of oncogenes that encode growth factors. v-sis-encoded mitogen can bind and activate platelet-derived growth factor (PDGF) receptors internally but these activated receptors must achieve a location on the cell surface in order to functionally couple with intracellular mitogenic signaling pathways. These findings have general implications concerning localization within the cell of critical targets of growth factor receptor action as well as approaches toward intervention with autocrine-associated malignancies. In a subset of the human tumor cell lines, a PDGF autocrine loop contributes to the uncontrolled proliferative drive. Some aspects of the PDGF system in human oncogenesis are highlighted in this paper.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalGann Monographs on Cancer Research
StatePublished - 1994
Externally publishedYes


Dive into the research topics of 'Platelet-derived growth factor system in human oncogenesis and its signaling pathways'. Together they form a unique fingerprint.

Cite this