Platelet-based drug delivery for cancer applications

Nerymar Ortiz-Otero, Zeinab Mohamed, Michael R. King

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

19 Scopus citations

Abstract

Platelets can be considered as the “guardian of hemostasis” where their main function is to maintain vascular integrity. In pathological conditions, the hemostatic role of platelets may be hijacked to stimulate disease progression. In 1865, Armand Trousseau was a pioneer in establishing the platelet-cancer metastasis relationship, which he eventually termed as Trousseau’s Syndrome to describe the deregulation of the hemostasis-associated pathways induced by cancer progression (Varki, Blood. 110(6):1723–9, 2007). Since these early studies, there has been an increase in experimental evidence not only to elucidate the role of platelets in cancer metastasis but also to create novel cancer therapies by targeting the platelet’s impact in metastasis. In this chapter, we discuss the contribution of platelets in facilitating tumor cell transit from the primary tumor to distant metastatic sites as well as novel cancer therapies based on platelet interactions.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages235-251
Number of pages17
DOIs
StatePublished - 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1092
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Abciximab
  • Anticoagulant
  • Artificial platelet
  • Cancer metastasis
  • Fibrinogen
  • Microthrombus cloak
  • Platelet
  • Tissue factor
  • Von willebrand factor

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