Plasticity of Pax-5-/- pre-B I cells

Ludovica Bruno, Christoph Schaniel, Antonius Rolink

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


In Pax-5 deficient mice, B cell development is blocked at the pre-B I cell stage. In contrast to their wild type counterparts, Pax-5-/- pre-B I cells posses an extraordinary developmental plasticity showing hematopoietic stem cell features such as pluripotency and self renewing capacity. Here we review the in vitro and in vivo evidence of this intriguing phenomenon.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalCells Tissues Organs
Issue number1
StatePublished - 2002
Externally publishedYes


  • Differentiation
  • Hematopoiesis
  • Self-renewal
  • Stem cell


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