Plasticity of Pax-5-/- pre-B I cells

Ludovica Bruno; Christoph Schaniel; Antonius Rolink

doi:10.1159/000057690

Plasticity of Pax-5^-/- pre-B I cells

Ludovica Bruno, Christoph Schaniel, Antonius Rolink

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In Pax-5 deficient mice, B cell development is blocked at the pre-B I cell stage. In contrast to their wild type counterparts, Pax-5^-/- pre-B I cells posses an extraordinary developmental plasticity showing hematopoietic stem cell features such as pluripotency and self renewing capacity. Here we review the in vitro and in vivo evidence of this intriguing phenomenon.

Original language	English
Pages (from-to)	38-43
Number of pages	6
Journal	Cells Tissues Organs
Volume	171
Issue number	1
DOIs	https://doi.org/10.1159/000057690
State	Published - 2002
Externally published	Yes

Keywords

Differentiation
Hematopoiesis
Self-renewal
Stem cell

Access to Document

10.1159/000057690

Cite this

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abstract = "In Pax-5 deficient mice, B cell development is blocked at the pre-B I cell stage. In contrast to their wild type counterparts, Pax-5-/- pre-B I cells posses an extraordinary developmental plasticity showing hematopoietic stem cell features such as pluripotency and self renewing capacity. Here we review the in vitro and in vivo evidence of this intriguing phenomenon.",

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KW - Differentiation

KW - Hematopoiesis

KW - Self-renewal

KW - Stem cell

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