Plasmapheresis as Sole Therapy in a Patient With Essential Mixed Cryoglobulinemia

Vera B. Delaney, Donald S. Fraley, David P. Segal, Frank J. Bruns

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18 Scopus citations


An 82-year-old woman with essential mixed cryoglobulinemia type II (IgM K IgG) presented with moderate renal failure and nephritic syndrome. Mesangiocapillary glomerulonephritis with mesangial and subendothelial granular deposits containing IgG, IgM, and C3 in conjunction with small-vessel vasculitis was seen on renal biopsy. Renal symptomatology preceded by a period of 10 months the development of leg ulcers and purpura. The onset of the skin lesions was accompanied by an acute decline of renal function and an increase in liver alkaline phosphatase. Plasmapheresis with a 50% plasma exchange each week over 12 weeks led to improvement in renal function, healing of leg ulcerations, disappearance of purpura, and a return to the baseline of alkaline phosphatase in association with the disappearance of circulating cryoglobulins.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalAmerican Journal of Kidney Diseases
Issue number1
StatePublished - 1984
Externally publishedYes


  • Plasmapheresis
  • cryoglobulinemia


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