TY - JOUR
T1 - Plasma reduced and total ascorbic acid in healthy women
T2 - Effects of smoking and oral contraception
AU - Basu, Jayasri
AU - Vermund, Sten H.
AU - Mikhail, Magdy
AU - Palan, Prabhudas R.
AU - Romney, Seymour L.
N1 - Funding Information:
We wish to thank Maria Chiodi for her active participation in patient recruitment: Christine Elcik for technical assistance: and Virginia Fahey for preparation of the manuscript. This study was supported in parts by the Health and Hospital Corporation of New York City and funds from the Friends of the Gynecologic Cancer Research, Albert Einstein College of Medicine.
PY - 1989/1
Y1 - 1989/1
N2 - This is the first report of both reduced (RAA) and total (TAA) plasma ascorbic acid levels in women who smoke and are on oral contraception. 155 normal healthy subjects were investigated. A study questionnaire was completed including age, method of contraception, smoking status, and food intake at breakfast, prior to attending the clinic. Biochemical assays were promptly carried out without knowledge of subjects's clinical or dietary status. One-way analysis of variance revealed that oral contraception per se, barrier or IUD methods have no effect on plasma ascorbic acid levels. The mean values (mg/dl ± SD) for plasma RAA between smokers and nonsmokers were 0.512 ± 0.241 and 0.601 ± 0.263; and that for TAA were 0.565 ± 0.232 and 0.682 ± 0.231, respectively. Significant decreases in both plasma RAA (p < 0.05) and TAA levels (p < 0.001) were observed in smokers. Age was an interacting variable. No association of smoking or oral contraceptive use was seen with RAA or TAA levels among women less than 26 years, but decreases in both RAA and TAA levels were evident among smokers aged 26 years or older. The present study emphasizes that total exposure to smoking, e.g., pack years, is a significant confounding variable in the study of plasma ascorbic acid levels.
AB - This is the first report of both reduced (RAA) and total (TAA) plasma ascorbic acid levels in women who smoke and are on oral contraception. 155 normal healthy subjects were investigated. A study questionnaire was completed including age, method of contraception, smoking status, and food intake at breakfast, prior to attending the clinic. Biochemical assays were promptly carried out without knowledge of subjects's clinical or dietary status. One-way analysis of variance revealed that oral contraception per se, barrier or IUD methods have no effect on plasma ascorbic acid levels. The mean values (mg/dl ± SD) for plasma RAA between smokers and nonsmokers were 0.512 ± 0.241 and 0.601 ± 0.263; and that for TAA were 0.565 ± 0.232 and 0.682 ± 0.231, respectively. Significant decreases in both plasma RAA (p < 0.05) and TAA levels (p < 0.001) were observed in smokers. Age was an interacting variable. No association of smoking or oral contraceptive use was seen with RAA or TAA levels among women less than 26 years, but decreases in both RAA and TAA levels were evident among smokers aged 26 years or older. The present study emphasizes that total exposure to smoking, e.g., pack years, is a significant confounding variable in the study of plasma ascorbic acid levels.
UR - http://www.scopus.com/inward/record.url?scp=0024600145&partnerID=8YFLogxK
U2 - 10.1016/0010-7824(89)90017-6
DO - 10.1016/0010-7824(89)90017-6
M3 - Article
C2 - 2910648
AN - SCOPUS:0024600145
SN - 0010-7824
VL - 39
SP - 85
EP - 93
JO - Contraception
JF - Contraception
IS - 1
ER -