Plasma MHPG in depression: Effects of acute and chronic desipramine treatment

Dennis S. Charney; George R. Heninger; David E. Sternberg; Robert H. Roth

doi:10.1016/0165-1781(81)90051-2

Plasma MHPG in depression: Effects of acute and chronic desipramine treatment

Dennis S. Charney, George R. Heninger, David E. Sternberg, Robert H. Roth

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The effects of acute and chronic desmethylimipramine (DMI) administration on 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) in plasma and urine were examined in eight depressed inpatients. DMI treatment induced an immediate and continous highly significant reduction in plasma MHPG throughout the 30-day treatment period. This effect was not related to treatment response. In contrast to plasma MHPG, there was no uniform effect of DMI treatment on urinary MHPG. Chronic DMI treatment increased or did not change urinary MHPG in the three treatment responders and decreased urinary MHPG in five nonresponders. The correlation between plasma and urinary MHPG during the placebo period was not significant, and the effect of DMI treatment on the two measures differed markedly.

Original language	English
Pages (from-to)	217-229
Number of pages	13
Journal	Psychiatry Research
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(81)90051-2
State	Published - Oct 1981
Externally published	Yes

Keywords

Plasma MHPG
depression
desmethylimipramine
urinary MHPG

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10.1016/0165-1781(81)90051-2

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title = "Plasma MHPG in depression: Effects of acute and chronic desipramine treatment",

abstract = "The effects of acute and chronic desmethylimipramine (DMI) administration on 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) in plasma and urine were examined in eight depressed inpatients. DMI treatment induced an immediate and continous highly significant reduction in plasma MHPG throughout the 30-day treatment period. This effect was not related to treatment response. In contrast to plasma MHPG, there was no uniform effect of DMI treatment on urinary MHPG. Chronic DMI treatment increased or did not change urinary MHPG in the three treatment responders and decreased urinary MHPG in five nonresponders. The correlation between plasma and urinary MHPG during the placebo period was not significant, and the effect of DMI treatment on the two measures differed markedly.",

keywords = "Plasma MHPG, depression, desmethylimipramine, urinary MHPG",

author = "Charney, \{Dennis S.\} and Heninger, \{George R.\} and Sternberg, \{David E.\} and Roth, \{Robert H.\}",

note = "Funding Information: Acknowledgments. This study was supported in part by the State of Connecticut, USPHS Grants MH-25,642, MH-14,276, MH-30,929, and MH-18,949. Wethankthe nurses of the Clinical Research Unit for their excellent clinical care and symptom ratings. Gratitude is also extended to Karen Hafstad, R.N., Paul Bellmore, Robert Reynolds, Ellen Clover, Susan Giddings, and Patty Burzynski for technical and secretarial help.",

year = "1981",

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doi = "10.1016/0165-1781(81)90051-2",

language = "English",

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journal = "Psychiatry Research",

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AU - Charney, Dennis S.

AU - Heninger, George R.

AU - Sternberg, David E.

AU - Roth, Robert H.

N1 - Funding Information: Acknowledgments. This study was supported in part by the State of Connecticut, USPHS Grants MH-25,642, MH-14,276, MH-30,929, and MH-18,949. Wethankthe nurses of the Clinical Research Unit for their excellent clinical care and symptom ratings. Gratitude is also extended to Karen Hafstad, R.N., Paul Bellmore, Robert Reynolds, Ellen Clover, Susan Giddings, and Patty Burzynski for technical and secretarial help.

PY - 1981/10

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N2 - The effects of acute and chronic desmethylimipramine (DMI) administration on 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) in plasma and urine were examined in eight depressed inpatients. DMI treatment induced an immediate and continous highly significant reduction in plasma MHPG throughout the 30-day treatment period. This effect was not related to treatment response. In contrast to plasma MHPG, there was no uniform effect of DMI treatment on urinary MHPG. Chronic DMI treatment increased or did not change urinary MHPG in the three treatment responders and decreased urinary MHPG in five nonresponders. The correlation between plasma and urinary MHPG during the placebo period was not significant, and the effect of DMI treatment on the two measures differed markedly.

AB - The effects of acute and chronic desmethylimipramine (DMI) administration on 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) in plasma and urine were examined in eight depressed inpatients. DMI treatment induced an immediate and continous highly significant reduction in plasma MHPG throughout the 30-day treatment period. This effect was not related to treatment response. In contrast to plasma MHPG, there was no uniform effect of DMI treatment on urinary MHPG. Chronic DMI treatment increased or did not change urinary MHPG in the three treatment responders and decreased urinary MHPG in five nonresponders. The correlation between plasma and urinary MHPG during the placebo period was not significant, and the effect of DMI treatment on the two measures differed markedly.

KW - Plasma MHPG

KW - depression

KW - desmethylimipramine

KW - urinary MHPG

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VL - 5

SP - 217

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JO - Psychiatry Research

JF - Psychiatry Research

IS - 2

ER -

Plasma MHPG in depression: Effects of acute and chronic desipramine treatment

Abstract

Keywords

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