Plasma interleukin-10 levels and adverse outcomes in acute coronary syndrome

Erdal Cavusoglu, Jonathan D. Marmur, Mohammad R. Hojjati, Vineet Chopra, Mitul Butala, Rakesh Subnani, Mohammad S. Huda, Sunitha Yanamadala, Cyril Ruwende, Calvin Eng, David J. Pinsky

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Purpose or Background: Interleukin (IL)-10 is an immunoregulatory cytokine that is produced by a variety of cell types, such as macrophages and activated monocytes. IL-10 possesses numerous anti-inflammatory, anti-thrombotic and anti-atherosclerotic properties. Furthermore, patients with acute coronary syndrome have been demonstrated to have reduced levels of IL-10 compared to their stable counterparts. For these reasons, it has been proposed that IL-10 plays a protective role in both atherogenesis and plaque vulnerability. However, 2 short-term studies on the prognostic utility of IL-10 in patients with acute coronary syndrome have provided conflicting results, with one study showing that reduced levels of IL-10 were predictors of adverse outcomes and another showing that elevated levels predicted poor outcomes. The objective of the present study was to investigate the long-term prognostic significance of baseline IL-10 levels in patients with acute coronary syndrome. Methods: Baseline plasma IL-10 levels were measured in 193 well-characterized male patients with acute coronary syndrome who were referred for coronary angiography and followed prospectively for 5 years for the development of major adverse cardiovascular events. Results: After controlling for a variety of baseline variables (including established biomarkers such as high-sensitivity C-reactive protein and N-terminal-pro-B-type natriuretic peptide), plasma IL-10 levels (whether analyzed as a continuous variable or as a categorical variable using receiver operating characteristic-derived cut point) were a strong and independent predictor of the composite outcome of death or non-fatal myocardial infarction when using a Cox proportional hazards model. Conclusions: These data demonstrate that, despite biologic plausibility for IL-10 as being a cardioprotective cytokine, elevated baseline plasma levels of IL-10 are a strong and independent predictor of long-term adverse cardiovascular outcomes in patients with acute coronary syndrome.

Original languageEnglish
Pages (from-to)724-730
Number of pages7
JournalAmerican Journal of Medicine
Volume124
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

Keywords

  • Acute coronary syndrome
  • Biomarker
  • Inflammation
  • Interleukin-11
  • Prognosis

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