Abstract
The 'blocking activity' of plasma samples from 24 patients with advanced colorectal cancer were studied by three different lymphocyte proliferation assays: i) phytohemagglutinin (PHA) dependent proliferation of mononuclear cells (MNC) from cancer patients in autologous vs. normal pooled plasma at optimal concentration of PHA, ii) PHA-dependent proliferation of normal MNC in cancer vs. normal plasma samples at different plasma- and PHA-concentrations, and iii) interleukin-2 (IL-2) concentrations. The significantly decreased lymphocyte proliferation of cancer patients could not be restored by normal plasma. Cancer plasma exerted a nonspecific blocking activity at suboptimal PHA concentration. Preincubations of PHA and plasma decreased lymphocyte proliferation. The proliferation of IL-2 dependent T-cells was not inhibited by plasma of cancer patients. The implications of these findings are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 127-131 |
| Number of pages | 5 |
| Journal | Tumor Diagnostik und Therapie |
| Volume | 13 |
| Issue number | 4 |
| State | Published - 1992 |
| Externally published | Yes |