TY - JOUR
T1 - Plasma diamine oxidase in pregnancy complicated by diabetes mellitus
AU - Southren, A. Louis
AU - Weingold, Allan B.
AU - Kobayashi, Yutaka
AU - Sherman, David H.
AU - Grimaldi, Richard
AU - Gold, Edwin M.
N1 - Funding Information:
Supported by Grant U-1714 of the Health Research Council of the City of New York and Grant H-192 of the Children’s Bureau, Welfare Administration, Department of Health, Education and Welfare, Washington, D. C.
PY - 1968/8/1
Y1 - 1968/8/1
N2 - Serial plasma diamine oxidase (DAO) titers and urinary pregnanediol and estriol excretions were measured in 41 pregnancies complicated by diabetes mellitus. Thirty-six per cent of the plasma enzyme titers were abnormally low in the Class A and 68 per cent in the combined Class B, C, and D diabetic pregnancies. All infants in the Class A diabetic group were born alive while there were 4 stillbirths in the Class B, C, and D diabetic patients. In each pregnancy resulting in a stillbirth, the plasma DAO curves were abnormally low from early pregnancy. Urinary pregnanediol excretions were within the normal range in each of the cases studied. In common with plasma DAO, urinary estriol appeared to correlate with the severity of the diabetic state. However, as with the plasma enzyme, abnormally low urinary estriol excretion was frequently associated with live births. It is our concept that low plasma DAO pregnancies represent fetuses at continuous "high risk".
AB - Serial plasma diamine oxidase (DAO) titers and urinary pregnanediol and estriol excretions were measured in 41 pregnancies complicated by diabetes mellitus. Thirty-six per cent of the plasma enzyme titers were abnormally low in the Class A and 68 per cent in the combined Class B, C, and D diabetic pregnancies. All infants in the Class A diabetic group were born alive while there were 4 stillbirths in the Class B, C, and D diabetic patients. In each pregnancy resulting in a stillbirth, the plasma DAO curves were abnormally low from early pregnancy. Urinary pregnanediol excretions were within the normal range in each of the cases studied. In common with plasma DAO, urinary estriol appeared to correlate with the severity of the diabetic state. However, as with the plasma enzyme, abnormally low urinary estriol excretion was frequently associated with live births. It is our concept that low plasma DAO pregnancies represent fetuses at continuous "high risk".
UR - http://www.scopus.com/inward/record.url?scp=0014323668&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(68)90271-8
DO - 10.1016/0002-9378(68)90271-8
M3 - Article
C2 - 4969094
AN - SCOPUS:0014323668
SN - 0002-9378
VL - 101
SP - 899
EP - 908
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 7
ER -