Plasma desorption characterization of glucuronide and glutathione conjugates derived from bilirubin

Catherine Fenselau; Rong Wang; G. B. Odell; William Mogilevsky

doi:10.1016/0168-1176(89)83033-2

Plasma desorption characterization of glucuronide and glutathione conjugates derived from bilirubin

Catherine Fenselau, Rong Wang, G. B. Odell, William Mogilevsky

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Plasma desorption was used for the first successful analysis by mass spectrometry of the underivatized mono- and diglucuronides of bilirubin. The method was also extended to characterize three novel metabolites formed by Gunn rats from the dimethyl diester of bilirubin. Based on mass spectrometry, chromatography and chemical degradation, these structures are proposed to be isomeric glutathione conjugates of dimethyl diesters of epoxybilirubins. Five measurements of mass of the M + H⁺ ions of one of the glutathione conjugates made over 17 months had an average value of 936.8 u and a standard deviation of ±0.5 u.

Original language	English
Pages (from-to)	289-295
Number of pages	7
Journal	International Journal of Mass Spectrometry and Ion Processes
Volume	92
Issue number	C
DOIs	https://doi.org/10.1016/0168-1176(89)83033-2
State	Published - 15 Sep 1989
Externally published	Yes

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title = "Plasma desorption characterization of glucuronide and glutathione conjugates derived from bilirubin",

abstract = "Plasma desorption was used for the first successful analysis by mass spectrometry of the underivatized mono- and diglucuronides of bilirubin. The method was also extended to characterize three novel metabolites formed by Gunn rats from the dimethyl diester of bilirubin. Based on mass spectrometry, chromatography and chemical degradation, these structures are proposed to be isomeric glutathione conjugates of dimethyl diesters of epoxybilirubins. Five measurements of mass of the M + H+ ions of one of the glutathione conjugates made over 17 months had an average value of 936.8 u and a standard deviation of ±0.5 u.",

author = "Catherine Fenselau and Rong Wang and Odell, {G. B.} and William Mogilevsky",

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T1 - Plasma desorption characterization of glucuronide and glutathione conjugates derived from bilirubin

AU - Fenselau, Catherine

AU - Wang, Rong

AU - Odell, G. B.

AU - Mogilevsky, William

PY - 1989/9/15

Y1 - 1989/9/15

N2 - Plasma desorption was used for the first successful analysis by mass spectrometry of the underivatized mono- and diglucuronides of bilirubin. The method was also extended to characterize three novel metabolites formed by Gunn rats from the dimethyl diester of bilirubin. Based on mass spectrometry, chromatography and chemical degradation, these structures are proposed to be isomeric glutathione conjugates of dimethyl diesters of epoxybilirubins. Five measurements of mass of the M + H+ ions of one of the glutathione conjugates made over 17 months had an average value of 936.8 u and a standard deviation of ±0.5 u.

AB - Plasma desorption was used for the first successful analysis by mass spectrometry of the underivatized mono- and diglucuronides of bilirubin. The method was also extended to characterize three novel metabolites formed by Gunn rats from the dimethyl diester of bilirubin. Based on mass spectrometry, chromatography and chemical degradation, these structures are proposed to be isomeric glutathione conjugates of dimethyl diesters of epoxybilirubins. Five measurements of mass of the M + H+ ions of one of the glutathione conjugates made over 17 months had an average value of 936.8 u and a standard deviation of ±0.5 u.

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U2 - 10.1016/0168-1176(89)83033-2

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JO - International Journal of Mass Spectrometry and Ion Processes

JF - International Journal of Mass Spectrometry and Ion Processes

IS - C

ER -

Plasma desorption characterization of glucuronide and glutathione conjugates derived from bilirubin

Abstract

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