TY - JOUR
T1 - Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients
AU - Yano, Yuichiro
AU - Toshinai, Koji
AU - Inokuchi, Takashi
AU - Kangawa, Kenji
AU - Shimada, Kazuyuki
AU - Kario, Kazuomi
AU - Nakazato, Masamitsu
N1 - Funding Information:
This study was partly supported by a grant-in-aid from the Foundation for the Development of the Community (Y.Y.). The authors are grateful for the dedicated work of our staff. We also thank T. Nagatomo, K. Kai, E. Kusao, M. Kawano, T. Hidaka, G. Nakamura, and S. Matsuda for their excellent support.
PY - 2009/6
Y1 - 2009/6
N2 - Objective: The coming obesity epidemic in elderly persons necessitates the establishment of new and easy-to-use cardiometabolic markers to identify individuals most likely to develop atherosclerosis among hypertensives. Methods: We measured plasma HMW adiponectin and des-acyl ghrelin levels, and carotid-artery intima-media thickness (cIMT) in 263 elderly hypertensives (mean 72.6 years; 37%men). Other cardiometabolic markers, including metabolites, inflammation, and hemostasis, were also measured. Results and conclusion: Both HMW adiponectin and des-acyl ghrelin levels were inversely correlated with obesity. The HMW adiponectin level was favorably associated with glucose and lipid metabolites, PAI-1 (all P < 0.05), and hs-CRP (P = 0.07) after adjustment for age, sex, and BMI; however, it had no correlations with cIMT. In contrast, although there were no correlations between des-acyl ghrelin and cardiometabolic markers, except for a positive association with the nitrite/nitrate (NOx) level (P = 0.002), des-acyl ghrelin had a significant inverse correlation with cIMT (P = 0.003). A multivariable regression analysis showed that des-acyl ghrelin, but not HMW adiponectin, was significantly associated with cIMT after adjusting for age, obesity, sex, smoking, 24-h BP, and other cardiometabolic factors (β = -0.178, P = 0.001). Moreover, the increased risk of cIMT among those with abdominal obesity compared with non-obesity (0.833 ± 0.185 mm vs. 0.782 ± 0.163 mm, P = 0.019) was explained by the elevated 24-h BP and reduced des-acyl ghrelin level, but not by other cardiometabolic parameters. These associations were unchanged after adding NOx to the model. In conclusion, the des-acyl ghrelin level is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensives, and the pathologic pathway linking these factors is independent of its NO bioactivity.
AB - Objective: The coming obesity epidemic in elderly persons necessitates the establishment of new and easy-to-use cardiometabolic markers to identify individuals most likely to develop atherosclerosis among hypertensives. Methods: We measured plasma HMW adiponectin and des-acyl ghrelin levels, and carotid-artery intima-media thickness (cIMT) in 263 elderly hypertensives (mean 72.6 years; 37%men). Other cardiometabolic markers, including metabolites, inflammation, and hemostasis, were also measured. Results and conclusion: Both HMW adiponectin and des-acyl ghrelin levels were inversely correlated with obesity. The HMW adiponectin level was favorably associated with glucose and lipid metabolites, PAI-1 (all P < 0.05), and hs-CRP (P = 0.07) after adjustment for age, sex, and BMI; however, it had no correlations with cIMT. In contrast, although there were no correlations between des-acyl ghrelin and cardiometabolic markers, except for a positive association with the nitrite/nitrate (NOx) level (P = 0.002), des-acyl ghrelin had a significant inverse correlation with cIMT (P = 0.003). A multivariable regression analysis showed that des-acyl ghrelin, but not HMW adiponectin, was significantly associated with cIMT after adjusting for age, obesity, sex, smoking, 24-h BP, and other cardiometabolic factors (β = -0.178, P = 0.001). Moreover, the increased risk of cIMT among those with abdominal obesity compared with non-obesity (0.833 ± 0.185 mm vs. 0.782 ± 0.163 mm, P = 0.019) was explained by the elevated 24-h BP and reduced des-acyl ghrelin level, but not by other cardiometabolic parameters. These associations were unchanged after adding NOx to the model. In conclusion, the des-acyl ghrelin level is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensives, and the pathologic pathway linking these factors is independent of its NO bioactivity.
KW - Atherosclerosis
KW - Des-acyl ghrelin
KW - Elderly
KW - HMW adiponectin
KW - Obesity
UR - https://www.scopus.com/pages/publications/67349142916
U2 - 10.1016/j.atherosclerosis.2008.10.013
DO - 10.1016/j.atherosclerosis.2008.10.013
M3 - Article
C2 - 19041092
AN - SCOPUS:67349142916
SN - 0021-9150
VL - 204
SP - 590
EP - 594
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -