Plasma cyclic adenosine-3', 5'-monophosphate response to glucagon in patients with liver disease

Terry F. Davies, Ken Prudhoe, Adrian P. Douglas

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The change in plasma cyclic adenosine-3', 5'-monophosphate (AMP) was measured after intravenous injection of 1 mg of glucagon in 10 normal subjects and 30 patients with various forms of liver disease. Patients with cirrhosis and those with intrahepatic cholestasis responded normally but in patients with extrahepatic obstruction the plasma cyclic AMP response was considerably increased. Six of the eight patients with cirrhosis and a surgically created portacaval shunt had very reduced responses. This test may prove to be diagnostically important, particularly in differentiating surgical from non-surgical jaundice.

Original languageEnglish
Pages (from-to)931-933
Number of pages3
JournalThe BMJ
Volume1
Issue number6015
DOIs
StatePublished - 17 Apr 1976
Externally publishedYes

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