TY - JOUR
T1 - Plasma concentrations of lipophilic persistent organic pollutants and glucose homeostasis in youth populations
AU - Baumert, Brittney O.
AU - Goodrich, Jesse A.
AU - Hu, Xin
AU - Walker, Douglas I.
AU - Alderete, Tanya L.
AU - Chen, Zhanghua
AU - Valvi, Damaskini
AU - Rock, Sarah
AU - Berhane, Kiros
AU - Gilliland, Frank D.
AU - Goran, Michael I.
AU - Jones, Dean P.
AU - Conti, David V.
AU - Chatzi, Leda
N1 - Funding Information:
The results reported herein correspond to specific aims of grant R01ES029944 to Dr. Chatzi from the National Institute of Environmental Health Science (NIEHS). Additional funding from NIEHS supported Dr. Chatzi ( R01ES030691 , R21ES029681 , R01ES030364 , R21ES028903 , and P30ES007048 ), Dr. Baumert ( R01ES030691 ), Dr. Goodrich ( T32-ES013678 ), Dr. Chen ( R00ES027870 ), Dr. Valvi ( R21ES029328 , K12ES033594 , P30ES023515 ), Dr. Goran ( RO1 DK 59211 ), Dr. Jones ( U2CES030163 , P30ES019776 , R24ES029490 , R01ES032189 , R21ES031824 ). The Southern California Children's Environmental Health Center grants funded by NIEHS ( 5P01ES022845-03 and 5P30ES007048 ) and United States Environmental Protection Agency ( RD83544101 ) and the Hastings Foundation . The Study of Latino Adolescents at Risk of Type 2 Diabetes grant funded by The National Institutes of Health (NIH).
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/9
Y1 - 2022/9
N2 - Background: Exposure to lipophilic persistent organic pollutants (POPs) is ubiquitous. POPs are metabolic disrupting chemicals and are potentially diabetogenic. Methods: Using a multi-cohort study including overweight adolescents from the Study of Latino Adolescents at Risk (SOLAR, N = 301, 2001–2012) and young adults from the Southern California Children's Health Study (CHS, N = 135, 2014–2018), we examined associations of POPs and risk factors for type 2 diabetes. SOLAR participants underwent annual visits for a median of 2.2 years and CHS participants performed a single visit, during which a 2-h oral glucose tolerance test was performed. Linear mixed models were used to examine associations between plasma concentrations of POPs [4,4′-dichlorodiphenyldichloroethylene (4,4′-DDE), hexachlorobenzene (HCB), PCBs-153, 138, 118, 180 and PBDEs-154, 153, 100, 85, 47] and changes in glucose homeostasis across age and pubertal stage. Results: In SOLAR, exposure to HCB, PCB-118, and PBDE-153 was associated with dysregulated glucose metabolism. For example, each two-fold increase in HCB was associated with approximately 2 mg/dL higher glucose concentrations at 30 min (p = 0.001), 45 min (p = 0.0006), and 60 min (p = 0.03) post glucose challenge. Compared to individuals with low levels of PCB-118, individuals with high levels exhibited a 4.7 mg/dL (p = 0.02) higher glucose concentration at 15 min and a 3.6 mg/dL (p = 0.01) higher glucose concentration at 30 min. The effects observed with exposure to organochlorine compounds were independent of pubertal stages. PBDE-153 was associated with the development of dysregulated glucose metabolism beginning in late puberty. At Tanner stage 4, exposure to PBDE-153 was associated with a 12.7 mg/dL higher 60-min glucose concentration (p = 0.009) and a 16.1 mg*dl−1*hr−1 higher glucose AUC (p = 0.01). These associations persisted at Tanner 5. In CHS, PBDE-153 and total PBDE were associated with similar increases in glucose concentrations. Conclusion: Our results suggest that childhood exposure to lipophilic POPs is associated with dysregulated glucose metabolism.
AB - Background: Exposure to lipophilic persistent organic pollutants (POPs) is ubiquitous. POPs are metabolic disrupting chemicals and are potentially diabetogenic. Methods: Using a multi-cohort study including overweight adolescents from the Study of Latino Adolescents at Risk (SOLAR, N = 301, 2001–2012) and young adults from the Southern California Children's Health Study (CHS, N = 135, 2014–2018), we examined associations of POPs and risk factors for type 2 diabetes. SOLAR participants underwent annual visits for a median of 2.2 years and CHS participants performed a single visit, during which a 2-h oral glucose tolerance test was performed. Linear mixed models were used to examine associations between plasma concentrations of POPs [4,4′-dichlorodiphenyldichloroethylene (4,4′-DDE), hexachlorobenzene (HCB), PCBs-153, 138, 118, 180 and PBDEs-154, 153, 100, 85, 47] and changes in glucose homeostasis across age and pubertal stage. Results: In SOLAR, exposure to HCB, PCB-118, and PBDE-153 was associated with dysregulated glucose metabolism. For example, each two-fold increase in HCB was associated with approximately 2 mg/dL higher glucose concentrations at 30 min (p = 0.001), 45 min (p = 0.0006), and 60 min (p = 0.03) post glucose challenge. Compared to individuals with low levels of PCB-118, individuals with high levels exhibited a 4.7 mg/dL (p = 0.02) higher glucose concentration at 15 min and a 3.6 mg/dL (p = 0.01) higher glucose concentration at 30 min. The effects observed with exposure to organochlorine compounds were independent of pubertal stages. PBDE-153 was associated with the development of dysregulated glucose metabolism beginning in late puberty. At Tanner stage 4, exposure to PBDE-153 was associated with a 12.7 mg/dL higher 60-min glucose concentration (p = 0.009) and a 16.1 mg*dl−1*hr−1 higher glucose AUC (p = 0.01). These associations persisted at Tanner 5. In CHS, PBDE-153 and total PBDE were associated with similar increases in glucose concentrations. Conclusion: Our results suggest that childhood exposure to lipophilic POPs is associated with dysregulated glucose metabolism.
KW - Flame retardants
KW - Obesogens
KW - Organochlorines
KW - Pesticides
KW - Polybrominated compounds
KW - Type II diabetes
UR - http://www.scopus.com/inward/record.url?scp=85128310853&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2022.113296
DO - 10.1016/j.envres.2022.113296
M3 - Article
C2 - 35447156
AN - SCOPUS:85128310853
SN - 0013-9351
VL - 212
JO - Environmental Research
JF - Environmental Research
M1 - 113296
ER -