Plasma Biomarkers in Graft-versus-Host Disease: A New Era?

Sophie Paczesny; John E. Levine; Thomas M. Braun; James L.M. Ferrara

doi:10.1016/j.bbmt.2008.10.027

Plasma Biomarkers in Graft-versus-Host Disease: A New Era?

Sophie Paczesny, John E. Levine, Thomas M. Braun, James L.M. Ferrara

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Acute graft versus host disease (GVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). The diagnosis of acute GVHD is based on strictly clinical criteria and its severity also determined by these criteria. Currently, there is no validated diagnostic blood test for acute GVHD. This review will summarize proteomics approaches to identify biomarkers for GVHD in the plasma with diagnostic, prognostic and predictive value. If successful, these studies could establish a novel biomarker panel that will contribute important information including long term survival, and that may eventually facilitate therapeutic decisions for allogeneic HCT patients.

Original language	English
Pages (from-to)	33-38
Number of pages	6
Journal	Biology of Blood and Marrow Transplantation
Volume	15
Issue number	1 SUPPL.
DOIs	https://doi.org/10.1016/j.bbmt.2008.10.027
State	Published - Jan 2009
Externally published	Yes

Keywords

Graft versus host disease
biomarkers panel
plasma biomarker
proteomics

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10.1016/j.bbmt.2008.10.027

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abstract = "Acute graft versus host disease (GVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). The diagnosis of acute GVHD is based on strictly clinical criteria and its severity also determined by these criteria. Currently, there is no validated diagnostic blood test for acute GVHD. This review will summarize proteomics approaches to identify biomarkers for GVHD in the plasma with diagnostic, prognostic and predictive value. If successful, these studies could establish a novel biomarker panel that will contribute important information including long term survival, and that may eventually facilitate therapeutic decisions for allogeneic HCT patients.",

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Plasma Biomarkers in Graft-versus-Host Disease: A New Era?

Abstract

Keywords

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