Plasma alpha amino-n-butyric acid to leucine ratio: An empirical biochemical marker of alcoholism

Spencer Shaw; Barry Stimmel; Charles S. Lieber

doi:10.1126/science.824734

Plasma alpha amino-n-butyric acid to leucine ratio: An empirical biochemical marker of alcoholism

Spencer Shaw
, Barry Stimmel
, Charles S. Lieber

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The plasma ratio of α-amino-n-butyric acid to leucine was elevated in ambulatory and hospitalized alcoholics as well as in baboons fed alcohol along with an adequate diet. There was a statistically significant positive correlation between this ratio and the degree of alcoholism assessed by three separate medical and psychological criteria in patients maintained on methadone.

Original language	English
Pages (from-to)	1057-1058
Number of pages	2
Journal	Science
Volume	194
Issue number	4269
DOIs	https://doi.org/10.1126/science.824734
State	Published - 1976
Externally published	Yes

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@article{e2a05d8d73a24f37b8f060e3cfa96d6a,

title = "Plasma alpha amino-n-butyric acid to leucine ratio: An empirical biochemical marker of alcoholism",

abstract = "The plasma ratio of α-amino-n-butyric acid to leucine was elevated in ambulatory and hospitalized alcoholics as well as in baboons fed alcohol along with an adequate diet. There was a statistically significant positive correlation between this ratio and the degree of alcoholism assessed by three separate medical and psychological criteria in patients maintained on methadone.",

author = "Spencer Shaw and Barry Stimmel and Lieber, \{Charles S.\}",

year = "1976",

doi = "10.1126/science.824734",

language = "English",

volume = "194",

pages = "1057--1058",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4269",

}

TY - JOUR

T1 - Plasma alpha amino-n-butyric acid to leucine ratio

T2 - An empirical biochemical marker of alcoholism

AU - Shaw, Spencer

AU - Stimmel, Barry

AU - Lieber, Charles S.

PY - 1976

Y1 - 1976

N2 - The plasma ratio of α-amino-n-butyric acid to leucine was elevated in ambulatory and hospitalized alcoholics as well as in baboons fed alcohol along with an adequate diet. There was a statistically significant positive correlation between this ratio and the degree of alcoholism assessed by three separate medical and psychological criteria in patients maintained on methadone.

AB - The plasma ratio of α-amino-n-butyric acid to leucine was elevated in ambulatory and hospitalized alcoholics as well as in baboons fed alcohol along with an adequate diet. There was a statistically significant positive correlation between this ratio and the degree of alcoholism assessed by three separate medical and psychological criteria in patients maintained on methadone.

UR - https://www.scopus.com/pages/publications/0017297820

U2 - 10.1126/science.824734

DO - 10.1126/science.824734

M3 - Article

C2 - 824734

AN - SCOPUS:0017297820

SN - 0036-8075

VL - 194

SP - 1057

EP - 1058

JO - Science

JF - Science

IS - 4269

ER -

Plasma alpha amino-n-butyric acid to leucine ratio: An empirical biochemical marker of alcoholism

Abstract

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