Plaque-forming cells in autoimmune thyroid disease

Irene Weiss, Erica De Bernardo, Terry F. Davies

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Peripheral mononuclear cells from patients with autoimmune thyroiditis were evaluated using antigen-specific (human thyroglobulin (hTg)) and nonspecific (protein A) reverse hemolytic plaque-forming cell assays. Polyclonal stimulation (using pokeweed mitogen) of protein A-PFC was similar in patients and normal control subjects but hTg-PFC were only detected in patients with autoimmune thyroid disease. hTg itself was a nonspecific mitogen as judged by increases in protein A-PFC in both groups and similarly induced hTg-PFC in patients with autoimune thyroiditis. Both protein A-PFC and hTg-PFC were also induced in patients by coincubation with irradiated peripheral mononuclear cells but there was significantly less enhancement of the specific compared to the nonspecific plaque-forming cells. These data provided additional evidence to support the concept of a specific B-cell defect in autoimmune thyroid disease.

Original languageEnglish
Pages (from-to)50-57
Number of pages8
JournalClinical Immunology and Immunopathology
Volume23
Issue number1
DOIs
StatePublished - Apr 1982

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