TY - JOUR
T1 - Plaque disruption and thrombosis in unstable angina pectoris
AU - Chesebro, James H.
AU - Zoldhelyi, Pierre
AU - Fuster, Valentin
PY - 1991/11/4
Y1 - 1991/11/4
N2 - Therapeutic strategies and clinical trials in unstable angina should be based on the pathogenesis, risk, and mechanisms of thrombosis. The mechanisms of thrombosis and the differences in the effects of anticoagulant, antithrombotic, antifibrin, and antiplatelet drugs must be taken into account when determining the dosage and duration of therapy. Ignoring these principles may prevent identification of new therapy, increase the cost of new drug development and research, increase the cost of new drugs, and increase the cost of medical care.
AB - Therapeutic strategies and clinical trials in unstable angina should be based on the pathogenesis, risk, and mechanisms of thrombosis. The mechanisms of thrombosis and the differences in the effects of anticoagulant, antithrombotic, antifibrin, and antiplatelet drugs must be taken into account when determining the dosage and duration of therapy. Ignoring these principles may prevent identification of new therapy, increase the cost of new drug development and research, increase the cost of new drugs, and increase the cost of medical care.
UR - http://www.scopus.com/inward/record.url?scp=0025748576&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(91)90218-A
DO - 10.1016/0002-9149(91)90218-A
M3 - Article
C2 - 1951110
AN - SCOPUS:0025748576
SN - 0002-9149
VL - 68
SP - 9
EP - 15
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 12
ER -