TY - JOUR
T1 - Planar cell polarity pathway in kidney development, function and disease
AU - Torban, Elena
AU - Sokol, Sergei Y.
N1 - Funding Information:
The authors thank L. Gusella (Icahn School of Medicine at Mount Sinai, New York, NY, USA) for comments on the manuscript before submission. We apologize to those investigators whose studies we could not cite due to the constraints for space. The authors’ work was supported by grants from the Kidney Foundation of Canada KFOC1719 and the Canadian Institute of Health Research (MOP130315 and PJT-169082) to E.T. and National Institutes of Health grants (GM122492, HD092990, DE027665 and NS100759) to S.Y.S.
Publisher Copyright:
© 2021, Springer Nature Limited.
PY - 2021/6
Y1 - 2021/6
N2 - Planar cell polarity (PCP) refers to the coordinated orientation of cells in the tissue plane. Originally discovered and studied in Drosophila melanogaster, PCP is now widely recognized in vertebrates, where it is implicated in organogenesis. Specific sets of PCP genes have been identified. The proteins encoded by these genes become asymmetrically distributed to opposite sides of cells within a tissue plane and guide many processes that include changes in cell shape and polarity, collective cell movements or the uniform distribution of cell appendages. A unifying characteristic of these processes is that they often involve rearrangement of actomyosin. Mutations in PCP genes can cause malformations in organs of many animals, including humans. In the past decade, strong evidence has accumulated for a role of the PCP pathway in kidney development including outgrowth and branching morphogenesis of ureteric bud and podocyte development. Defective PCP signalling has been implicated in the pathogenesis of developmental kidney disorders of the congenital anomalies of the kidney and urinary tract spectrum. Understanding the origins, molecular constituents and cellular targets of PCP provides insights into the involvement of PCP molecules in normal kidney development and how dysfunction of PCP components may lead to kidney disease.
AB - Planar cell polarity (PCP) refers to the coordinated orientation of cells in the tissue plane. Originally discovered and studied in Drosophila melanogaster, PCP is now widely recognized in vertebrates, where it is implicated in organogenesis. Specific sets of PCP genes have been identified. The proteins encoded by these genes become asymmetrically distributed to opposite sides of cells within a tissue plane and guide many processes that include changes in cell shape and polarity, collective cell movements or the uniform distribution of cell appendages. A unifying characteristic of these processes is that they often involve rearrangement of actomyosin. Mutations in PCP genes can cause malformations in organs of many animals, including humans. In the past decade, strong evidence has accumulated for a role of the PCP pathway in kidney development including outgrowth and branching morphogenesis of ureteric bud and podocyte development. Defective PCP signalling has been implicated in the pathogenesis of developmental kidney disorders of the congenital anomalies of the kidney and urinary tract spectrum. Understanding the origins, molecular constituents and cellular targets of PCP provides insights into the involvement of PCP molecules in normal kidney development and how dysfunction of PCP components may lead to kidney disease.
UR - http://www.scopus.com/inward/record.url?scp=85100537622&partnerID=8YFLogxK
U2 - 10.1038/s41581-021-00395-6
DO - 10.1038/s41581-021-00395-6
M3 - Review article
C2 - 33547419
AN - SCOPUS:85100537622
SN - 1759-5061
VL - 17
SP - 369
EP - 385
JO - Nature Reviews Nephrology
JF - Nature Reviews Nephrology
IS - 6
ER -