@article{c65aa7c9450a4405a2e9e542808aad34,
title = "Placental mitochondrial DNA mutational load and perinatal outcomes: Findings from a multi-ethnic pregnancy cohort",
abstract = "Mitochondria fuel placental activity, with mitochondrial dysfunction implicated in several perinatal complications. We investigated placental mtDNA mutational load using NextGen sequencing in relation to birthweight and gestational length among 358 mother-newborn pairs. We found that higher heteroplasmy, especially in the hypervariable displacement loop region, was associated with shorter gestational length. Results were similar among male and female pregnancies, but stronger in magnitude among females. With regard to growth, we observed that higher mutational load was associated with lower birthweight-for-gestational age (BWGA) among females, but higher BWGA among males. These findings support potential sex-differential fetal biological strategies for coping with increased heteroplasmies.",
keywords = "Birthweight, Gestational age, Mitochondria, Placenta, Preterm, mtDNA",
author = "Whitney Cowell and Kelly Brunst and Elena Colicino and Li Zhang and Xiang Zhang and Bloomquist, {Tessa R.} and Baccarelli, {Andrea A.} and Wright, {Rosalind J.}",
note = "Funding Information: This work was supported by the National Heart, Lung, and Blood Institute under grant Nos. R01HL095606 (RJ Wright) and R01HL114396 (RJ Wright); the National Institute of Environmental Health Sciences (NIEHS) under grant Nos. R00ES024116 (KJ Brunst), P30ES006096 (KJ Brunst), P30ES023515 (RJ Wright) and K99ES032029 (W Cowell). Biobanking infrastructure was supported by the Mount Sinai Health System Clinical Translational Science Award from the National Center for Advancing Translational Sciences under grant No. UL1 TR001433 (RJ Wright). Publisher Copyright: {\textcopyright} 2019 Elsevier B.V. and Mitochondria Research Society. All rights reserved.",
year = "2021",
month = jul,
doi = "10.1016/j.mito.2021.06.006",
language = "English",
volume = "59",
pages = "267--275",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier",
}